Neuropsychiatric disorders in persons with severe traumatic brain injury: Prevalence, phenomenology, and relationship with demographic, clinical, and functional features

Paola Ciurli, Rita Formisano, Umberto Bivona, Anna Cantagallo, Paola Angelelli

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To characterize neuropsychiatric symptoms in a large group of individuals with severe traumatic brain injury (TBI) and to correlate these symptoms with demographic, clinical, and functional features. Methods: The Neuropsychiatric Inventory (NPI), a frequently used scale to assess behavioral, emotional, and motivational disorders in persons with neurological diseases, was administered to a sample of 120 persons with severe TBI. Controls were 77 healthy subjects. Results: A wide range of neuropsychiatric symptoms was found in the population with severe TBI: apathy (42%), irritability (37%), dysphoria/depressed mood (29%), disinhibition (28%), eating disturbances (27%), and agitation (24%). A clear relationship was also found with other demographic and clinical variables. Conclusion: Neuropsychiatric disorders constitute an important part of the comorbidity in populations with severe TBI. Our study emphasizes the importance of integrating an overall assessment of cognitive disturbances with a specific neuropsychiatric evaluation to improve clinical understanding and treatment of persons with TBI.

Original languageEnglish
Pages (from-to)116-126
Number of pages11
JournalJournal of Head Trauma Rehabilitation
Volume26
Issue number2
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Neuropsychiatric disorders
  • Neuropsychiatric Inventory
  • severe traumatic brain injury

ASJC Scopus subject areas

  • Rehabilitation
  • Clinical Neurology
  • Physical Therapy, Sports Therapy and Rehabilitation

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