Neuropsychiatric symptoms and interleukin-6 serum levels in acute stroke

Gianfranco Spalletta, Luca Cravello, Francesca Imperiale, Francesca Salani, Paola Bossù, Livio Picchetto, Marina Cao, Maurizia Rasura, Floriana Pazzelli, Francesco Orzi, Carlo Caltagirone, Robert G. Robinson, Claudia Cacciari

Research output: Contribution to journalArticle

Abstract

The role of interleukin-6 (IL-6) as a risk factor for developing depressive symptoms, neuropsychological impairment, and related functional and neurological symptom severity during the acute phase of ischemic stroke is still underexplored. Here, the authors assessed this issue, in 48 patients without significant clinical history for major medical illnesses or other factors that promote inflammation, 72 hours after a first-ever acute ischemic stroke. In the acute phase of ischemic stroke, increased IL-6 plays a key role in the onset of depressive disorders, apathy/amotivation, somatic symptoms of depression, and neurological/functional symptoms, resulting in higher disability and poor outcome of stroke patients.

Original languageEnglish
Pages (from-to)255-263
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume25
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Interleukin-6
Stroke
Serum
Depression
Apathy
Depressive Disorder
Inflammation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Neuropsychiatric symptoms and interleukin-6 serum levels in acute stroke. / Spalletta, Gianfranco; Cravello, Luca; Imperiale, Francesca; Salani, Francesca; Bossù, Paola; Picchetto, Livio; Cao, Marina; Rasura, Maurizia; Pazzelli, Floriana; Orzi, Francesco; Caltagirone, Carlo; Robinson, Robert G.; Cacciari, Claudia.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 25, No. 4, 2013, p. 255-263.

Research output: Contribution to journalArticle

Spalletta, G, Cravello, L, Imperiale, F, Salani, F, Bossù, P, Picchetto, L, Cao, M, Rasura, M, Pazzelli, F, Orzi, F, Caltagirone, C, Robinson, RG & Cacciari, C 2013, 'Neuropsychiatric symptoms and interleukin-6 serum levels in acute stroke', Journal of Neuropsychiatry and Clinical Neurosciences, vol. 25, no. 4, pp. 255-263. https://doi.org/10.1176/appi.neuropsych.12120399
Spalletta, Gianfranco ; Cravello, Luca ; Imperiale, Francesca ; Salani, Francesca ; Bossù, Paola ; Picchetto, Livio ; Cao, Marina ; Rasura, Maurizia ; Pazzelli, Floriana ; Orzi, Francesco ; Caltagirone, Carlo ; Robinson, Robert G. ; Cacciari, Claudia. / Neuropsychiatric symptoms and interleukin-6 serum levels in acute stroke. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2013 ; Vol. 25, No. 4. pp. 255-263.
@article{c1653903cf0646389bee232162d0fed1,
title = "Neuropsychiatric symptoms and interleukin-6 serum levels in acute stroke",
abstract = "The role of interleukin-6 (IL-6) as a risk factor for developing depressive symptoms, neuropsychological impairment, and related functional and neurological symptom severity during the acute phase of ischemic stroke is still underexplored. Here, the authors assessed this issue, in 48 patients without significant clinical history for major medical illnesses or other factors that promote inflammation, 72 hours after a first-ever acute ischemic stroke. In the acute phase of ischemic stroke, increased IL-6 plays a key role in the onset of depressive disorders, apathy/amotivation, somatic symptoms of depression, and neurological/functional symptoms, resulting in higher disability and poor outcome of stroke patients.",
author = "Gianfranco Spalletta and Luca Cravello and Francesca Imperiale and Francesca Salani and Paola Boss{\`u} and Livio Picchetto and Marina Cao and Maurizia Rasura and Floriana Pazzelli and Francesco Orzi and Carlo Caltagirone and Robinson, {Robert G.} and Claudia Cacciari",
year = "2013",
doi = "10.1176/appi.neuropsych.12120399",
language = "English",
volume = "25",
pages = "255--263",
journal = "Journal of Neuropsychiatry and Clinical Neurosciences",
issn = "0895-0172",
publisher = "American Psychiatric Publishing Inc.",
number = "4",

}

TY - JOUR

T1 - Neuropsychiatric symptoms and interleukin-6 serum levels in acute stroke

AU - Spalletta, Gianfranco

AU - Cravello, Luca

AU - Imperiale, Francesca

AU - Salani, Francesca

AU - Bossù, Paola

AU - Picchetto, Livio

AU - Cao, Marina

AU - Rasura, Maurizia

AU - Pazzelli, Floriana

AU - Orzi, Francesco

AU - Caltagirone, Carlo

AU - Robinson, Robert G.

AU - Cacciari, Claudia

PY - 2013

Y1 - 2013

N2 - The role of interleukin-6 (IL-6) as a risk factor for developing depressive symptoms, neuropsychological impairment, and related functional and neurological symptom severity during the acute phase of ischemic stroke is still underexplored. Here, the authors assessed this issue, in 48 patients without significant clinical history for major medical illnesses or other factors that promote inflammation, 72 hours after a first-ever acute ischemic stroke. In the acute phase of ischemic stroke, increased IL-6 plays a key role in the onset of depressive disorders, apathy/amotivation, somatic symptoms of depression, and neurological/functional symptoms, resulting in higher disability and poor outcome of stroke patients.

AB - The role of interleukin-6 (IL-6) as a risk factor for developing depressive symptoms, neuropsychological impairment, and related functional and neurological symptom severity during the acute phase of ischemic stroke is still underexplored. Here, the authors assessed this issue, in 48 patients without significant clinical history for major medical illnesses or other factors that promote inflammation, 72 hours after a first-ever acute ischemic stroke. In the acute phase of ischemic stroke, increased IL-6 plays a key role in the onset of depressive disorders, apathy/amotivation, somatic symptoms of depression, and neurological/functional symptoms, resulting in higher disability and poor outcome of stroke patients.

UR - http://www.scopus.com/inward/record.url?scp=84901318685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901318685&partnerID=8YFLogxK

U2 - 10.1176/appi.neuropsych.12120399

DO - 10.1176/appi.neuropsych.12120399

M3 - Article

C2 - 24247852

AN - SCOPUS:84901318685

VL - 25

SP - 255

EP - 263

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 4

ER -