Neuropsychiatric syndromes in dementia: Results from the European Alzheimer disease Consortium: Part I

Pauline Aalten, Frans R J Verhey, Marina Boziki, Roger Bullock, Eleanor Jane Byrne, Vincent Camus, Miriam Caputo, Debby Collins, Peter Paul De Deyn, Kazi Elina, Giovanni Frisoni, Nicola Girtler, Clive Holmes, Catherine Hurt, Anna Marriott, Patrizia Mecocci, Flavio Nobili, Pierre Jean Ousset, Emma Reynish, Eric SalmonMagda Tsolaki, Bruno Vellas, Philippe H. Robert

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aims: The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD). Methods: Cross-sectional data of 2,354 patients with AD from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis. Results: The results showed the presence of 4 neuropsychiatric subsyndromes: hyperactivity, psychosis, affective symptoms and apathy. The subsyndrome apathy was the most common, occurring in almost 65% of the patients. Conclusion: This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume24
Issue number6
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Alzheimer's disease
  • Dementia
  • Factor analysis
  • Neuropsychiatric Inventory
  • Neuropsychiatric syndromes
  • Subsyndromes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

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