Neuropsychological abnormalities in AIDS and asymptomatic HIV seropositive patients

G. Villa, D. Monteleone, C. Marra, A. Bartoli, A. Antinori, F. Pallavicini, E. Tamburrini, I. Izzi

Research output: Contribution to journalArticlepeer-review


Neuropsychological and immunological parameters were studied in 36 AIDS patients with early disease and without clinical, laboratory, and neuroradiological signs of CNS impairment, and also in 33 asymptomatic HIV seropositive subjects. Many AIDS patients performed abnormally on timed psychomotor tasks, tasks involving sequencing and "setshifting", and memory tasks stressing attention, learning, active retrieval, and monitoring of information. Asymptomatic HIV seropositive subjects as a group did not perform significantly worse than controls. However, on the basis of a cut off number of pathological performances on neuropsychological tasks, 52-8% of AIDS and 30 3% of asymptomatic HIV seropositive subjects had cognitive impairment, compared with 3.9% of HIV seronegative controls. Low values of CD4 + cells and of CD4 + /CD8 + ratio and high titres of P- 24 antigen in the blood prevailed among subjects with cognitive impairment, especially in the asymptomatic HIV seropositive group.

Original languageEnglish
Pages (from-to)878-884
Number of pages7
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number8
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology


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