Neuropsychological and event-related potential study in patients with systemic lupus erythematosus. Thirty-two patients affected by SLE have been examined with a battery of neuropsychological tests and with acoustic ERPs (P300).The aim of the study was to analyze the frequency of cognitive impairment in SLE patients and to compare psychometric with neurophysiologic data. Results showed the presence of neuropsychological deficits in 12 (37.5%) patients, and alterations of P300 latency in 6 (18.7%). ERP alterations were found significantly associated io memory deficits (p = 0.04) and MMSE abnormal scores (p = 0.03). P300 values correlated significantly with MMSE (P = 0.01; r 2 = 0.18) and Raven (p = 0.04; r 2 = 0.16) scores. The present study confirms the frequent occurrence of cognitive dysfunctions in SLE patients. ERP recordings together with neuropsychological tests may be useful methods to detect existing abnormalities in the course of the disease.
|Journal||Nuova Rivista di Neurologia|
|Publication status||Published - 1997|
- Cognitive function
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Clinical Neurology