Neuropsychological and functional study in a case of partial cerebellar agenesis

Paola Caroppo; Laura Orsi; Federico D'Agata; Bruno Baudino; Andrea Boghi; Federica Avidano; Mario Coriasco; Gianni Boris Bradac; Giancarlo Castellano; Roberto Mutani; Paolo Mortara

doi:10.1080/13554790902842029

Neuropsychological and functional study in a case of partial cerebellar agenesis

Paola Caroppo, Laura Orsi, Federico D'Agata, Bruno Baudino, Andrea Boghi, Federica Avidano, Mario Coriasco, Gianni Boris Bradac, Giancarlo Castellano, Roberto Mutani, Paolo Mortara

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Cerebellar agenesis is a rare disorder. We present the neurological and neuropsychological features of a patient with partial cerebellar agenesis (TZ), together with SPECT perfusion and fMRI activation during a finger tapping task. TZ shows only mild cerebellar signs, while neuropsychological testing discloses severe deficits in many domains, in accordance with the theorized role of the cerebellum in cognition. FMRI and SPECT demonstrate an activation and a symmetrical perfusion of the cerebellar remnants, that can be related to the residual cerebellar motor function. The left frontal and parieto-temporal cortex hypoper-fusion can explain the severe cognitive impairment and could be linked to the abnormal cerebellar development.

Original language	English
Pages (from-to)	373-383
Number of pages	11
Journal	Neurocase
Volume	15
Issue number	5
DOIs	https://doi.org/10.1080/13554790902842029
Publication status	Published - Oct 2009

Keywords

Cerebellar agenesis
Cerebellum
Cognitive functions development
fMRI
SPECT

ASJC Scopus subject areas

Clinical Neurology

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10.1080/13554790902842029

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Neuropsychological and functional study in a case of partial cerebellar agenesis. / Caroppo, Paola; Orsi, Laura; D'Agata, Federico; Baudino, Bruno; Boghi, Andrea; Avidano, Federica; Coriasco, Mario; Bradac, Gianni Boris; Castellano, Giancarlo; Mutani, Roberto; Mortara, Paolo.

In: Neurocase, Vol. 15, No. 5, 10.2009, p. 373-383.

Research output: Contribution to journal › Article › peer-review

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AU - Avidano, Federica

AU - Coriasco, Mario

AU - Bradac, Gianni Boris

AU - Castellano, Giancarlo

AU - Mutani, Roberto

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Neuropsychological and functional study in a case of partial cerebellar agenesis

Abstract

Keywords

ASJC Scopus subject areas

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