Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up

E. Bozzola, P. Bergonzini, M. Bozzola, A. E. Tozzi, M. Masci, C. Rossetti, E. Carloni, A. Villani

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Acute central nervous system (ACNS) infections such as meningitis, encephalitis and cerebellitis still cause morbidity and mortality among children. The aim of this study was to verify whether neuropsychological impairment may develop in ACNS survivors. METHODS: The study included pediatric patients affected by ACNS disorders, aged 3-16 years admitted to the Bambino Gesu Children Hospital, Rome from June 2013 till June 2015. The patients and their parents underwent a psychological interview and neuropsychological tests during the first week of hospital admission and 1 year after, during a follow-up control. Wilcoxon signed rank tests for paired data were conducted to verify if the results were statistically importance. Patients underwent a cognitive profile test through the Leiter international performance scale - revised, motor skills evaluation through the test of visual-motor integration and a psychopathological evaluation by the child behavior checklist. The K-SADS-PL test was administered in children 6-11 years old to check psychopathological disorders. RESULTS: Forty-four patients were included in the study. At the 1 year follow-up, "anxiety problems" (dependency, fears, worries, nervousness) developed in 47% of patients, "somatic problems" (aches, headaches, nausea, vomiting) in 29% and "affective problems" (crying, self-harming, worthlessness, guilt, tiredness, sadness) in 29%. Visual perception was statistically increased at the 1 year follow-up in our patient cohort (p = 0.0297), mainly among the meningitides group (p = 0.0189). Motor-coordination also increased at the follow-up check in the study participants (p = 0.0076), especially in the group affected by cerebellitis (p = 0.0302). CONCLUSIONS: Neuropsychological disorders are often difficult to recognize in the early stage. They must, however, be promptly identified through specific and standardized neuropsychological examinations in order to avoid long term sequelae in adulthood.
Original languageEnglish
Pages (from-to)96-017-0416-2
JournalItalian Journal of Pediatrics
Volume43
Issue number1
DOIs
Publication statusPublished - Oct 24 2017

Fingerprint

Central Nervous System Infections
Meningitis
Psychological Interviews
Anxiety
Crying
Psychological Tests
Child Mortality
Visual Perception
Motor Skills
Guilt
Neuropsychological Tests
Central Nervous System Diseases
Child Behavior
Encephalitis
Nonparametric Statistics
Checklist
Nausea
Fear
Vomiting
Headache

Keywords

  • Central nervous system infection
  • Neuropsychology
  • Psychological test

Cite this

Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up. / Bozzola, E.; Bergonzini, P.; Bozzola, M.; Tozzi, A. E.; Masci, M.; Rossetti, C.; Carloni, E.; Villani, A.

In: Italian Journal of Pediatrics, Vol. 43, No. 1, 24.10.2017, p. 96-017-0416-2.

Research output: Contribution to journalArticle

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T1 - Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up

AU - Bozzola, E.

AU - Bergonzini, P.

AU - Bozzola, M.

AU - Tozzi, A. E.

AU - Masci, M.

AU - Rossetti, C.

AU - Carloni, E.

AU - Villani, A.

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N2 - BACKGROUND: Acute central nervous system (ACNS) infections such as meningitis, encephalitis and cerebellitis still cause morbidity and mortality among children. The aim of this study was to verify whether neuropsychological impairment may develop in ACNS survivors. METHODS: The study included pediatric patients affected by ACNS disorders, aged 3-16 years admitted to the Bambino Gesu Children Hospital, Rome from June 2013 till June 2015. The patients and their parents underwent a psychological interview and neuropsychological tests during the first week of hospital admission and 1 year after, during a follow-up control. Wilcoxon signed rank tests for paired data were conducted to verify if the results were statistically importance. Patients underwent a cognitive profile test through the Leiter international performance scale - revised, motor skills evaluation through the test of visual-motor integration and a psychopathological evaluation by the child behavior checklist. The K-SADS-PL test was administered in children 6-11 years old to check psychopathological disorders. RESULTS: Forty-four patients were included in the study. At the 1 year follow-up, "anxiety problems" (dependency, fears, worries, nervousness) developed in 47% of patients, "somatic problems" (aches, headaches, nausea, vomiting) in 29% and "affective problems" (crying, self-harming, worthlessness, guilt, tiredness, sadness) in 29%. Visual perception was statistically increased at the 1 year follow-up in our patient cohort (p = 0.0297), mainly among the meningitides group (p = 0.0189). Motor-coordination also increased at the follow-up check in the study participants (p = 0.0076), especially in the group affected by cerebellitis (p = 0.0302). CONCLUSIONS: Neuropsychological disorders are often difficult to recognize in the early stage. They must, however, be promptly identified through specific and standardized neuropsychological examinations in order to avoid long term sequelae in adulthood.

AB - BACKGROUND: Acute central nervous system (ACNS) infections such as meningitis, encephalitis and cerebellitis still cause morbidity and mortality among children. The aim of this study was to verify whether neuropsychological impairment may develop in ACNS survivors. METHODS: The study included pediatric patients affected by ACNS disorders, aged 3-16 years admitted to the Bambino Gesu Children Hospital, Rome from June 2013 till June 2015. The patients and their parents underwent a psychological interview and neuropsychological tests during the first week of hospital admission and 1 year after, during a follow-up control. Wilcoxon signed rank tests for paired data were conducted to verify if the results were statistically importance. Patients underwent a cognitive profile test through the Leiter international performance scale - revised, motor skills evaluation through the test of visual-motor integration and a psychopathological evaluation by the child behavior checklist. The K-SADS-PL test was administered in children 6-11 years old to check psychopathological disorders. RESULTS: Forty-four patients were included in the study. At the 1 year follow-up, "anxiety problems" (dependency, fears, worries, nervousness) developed in 47% of patients, "somatic problems" (aches, headaches, nausea, vomiting) in 29% and "affective problems" (crying, self-harming, worthlessness, guilt, tiredness, sadness) in 29%. Visual perception was statistically increased at the 1 year follow-up in our patient cohort (p = 0.0297), mainly among the meningitides group (p = 0.0189). Motor-coordination also increased at the follow-up check in the study participants (p = 0.0076), especially in the group affected by cerebellitis (p = 0.0302). CONCLUSIONS: Neuropsychological disorders are often difficult to recognize in the early stage. They must, however, be promptly identified through specific and standardized neuropsychological examinations in order to avoid long term sequelae in adulthood.

KW - Central nervous system infection

KW - Neuropsychology

KW - Psychological test

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DO - 10.1186/s13052-017-0416-2 [doi]

M3 - Article

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SP - 96-017-0416-2

JO - Italian Journal of Pediatrics

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ER -