Neuropsychological aspects of tuberous sclerosis in relation to epilepsy and MRI findings

I. Jambaque, R. Cusmai, P. Curatolo, F. Cortesi, C. Perrot, O. Dulac

Research output: Contribution to journalArticlepeer-review


The neuropsychological performances, outcome of epilepsy and MRI topography of tubers of 23 children with tuberous sclerosis were reviewed. Seven children had normal intelligence, 10 had mental retardation, and six mental retardation and autism. An adverse association was found between the number of lesions and IQ, behaviour and severity of epilepsy. Posterior lesions, in addition to frontal-lobe dysfunction, were observed in children with autism. Tuberous sclerosis with well-defined cerebral lesions may represent a model for the relationship between different neuropsychiatric problems.

Original languageEnglish
Pages (from-to)698-705
Number of pages8
JournalDevelopmental Medicine and Child Neurology
Issue number8
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)


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