Abstract
We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent magnetic resonance imaging examination. MS performed worse than controls on all WAIS-P subtests and had learning, short- and long-term verbal memory impairment. Cognitive deficits were not related to abnormal emotional states, but were found to be associated with attentional process and information-processing speed impairment. Cognitive impairment did not correlate with severity of physical disability. The most severe memory deficits were found in patients with extensive periventricular damage.
Original language | English |
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Pages (from-to) | 124-128 |
Number of pages | 5 |
Journal | Acta Neurologica Scandinavica |
Volume | 86 |
Issue number | 2 |
Publication status | Published - 1992 |
Keywords
- attention
- cognitive functioning
- information processing speed
- MRI
- multiple sclerosis
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)