Neuropsychological assessment in MS: Clinical, neurophysiological and neuroradiological relationships

M. Maurelli; E. Marchioni; R. Cerretano; D. Bosone; R. Bergamaschi; A. Citterio; A. Martelli; L. Sibilla; F. Savoldi

Neuropsychological assessment in MS: Clinical, neurophysiological and neuroradiological relationships

M. Maurelli, E. Marchioni, R. Cerretano, D. Bosone, R. Bergamaschi, A. Citterio, A. Martelli, L. Sibilla, F. Savoldi

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent magnetic resonance imaging examination. MS performed worse than controls on all WAIS-P subtests and had learning, short- and long-term verbal memory impairment. Cognitive deficits were not related to abnormal emotional states, but were found to be associated with attentional process and information-processing speed impairment. Cognitive impairment did not correlate with severity of physical disability. The most severe memory deficits were found in patients with extensive periventricular damage.

Original language	English
Pages (from-to)	124-128
Number of pages	5
Journal	Acta Neurologica Scandinavica
Volume	86
Issue number	2
Publication status	Published - 1992

Keywords

attention
cognitive functioning
information processing speed
MRI
multiple sclerosis

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

Fingerprint Dive into the research topics of 'Neuropsychological assessment in MS: Clinical, neurophysiological and neuroradiological relationships'. Together they form a unique fingerprint.

Cite this

@article{e2902d83bdb74e7086aeebe055d764b3,

title = "Neuropsychological assessment in MS: Clinical, neurophysiological and neuroradiological relationships",

abstract = "We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent magnetic resonance imaging examination. MS performed worse than controls on all WAIS-P subtests and had learning, short- and long-term verbal memory impairment. Cognitive deficits were not related to abnormal emotional states, but were found to be associated with attentional process and information-processing speed impairment. Cognitive impairment did not correlate with severity of physical disability. The most severe memory deficits were found in patients with extensive periventricular damage.",

keywords = "attention, cognitive functioning, information processing speed, MRI, multiple sclerosis",

author = "M. Maurelli and E. Marchioni and R. Cerretano and D. Bosone and R. Bergamaschi and A. Citterio and A. Martelli and L. Sibilla and F. Savoldi",

year = "1992",

language = "English",

volume = "86",

pages = "124--128",

journal = "Acta Neurologica Scandinavica",

issn = "0001-6314",

publisher = "Wiley Blackwell",

number = "2",

}

TY - JOUR

T1 - Neuropsychological assessment in MS

T2 - Clinical, neurophysiological and neuroradiological relationships

AU - Maurelli, M.

AU - Marchioni, E.

AU - Cerretano, R.

AU - Bosone, D.

AU - Bergamaschi, R.

AU - Citterio, A.

AU - Martelli, A.

AU - Sibilla, L.

AU - Savoldi, F.

PY - 1992

Y1 - 1992

N2 - We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent magnetic resonance imaging examination. MS performed worse than controls on all WAIS-P subtests and had learning, short- and long-term verbal memory impairment. Cognitive deficits were not related to abnormal emotional states, but were found to be associated with attentional process and information-processing speed impairment. Cognitive impairment did not correlate with severity of physical disability. The most severe memory deficits were found in patients with extensive periventricular damage.

AB - We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent magnetic resonance imaging examination. MS performed worse than controls on all WAIS-P subtests and had learning, short- and long-term verbal memory impairment. Cognitive deficits were not related to abnormal emotional states, but were found to be associated with attentional process and information-processing speed impairment. Cognitive impairment did not correlate with severity of physical disability. The most severe memory deficits were found in patients with extensive periventricular damage.

KW - attention

KW - cognitive functioning

KW - information processing speed

KW - MRI

KW - multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=0026713144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026713144&partnerID=8YFLogxK

M3 - Article

C2 - 1414220

AN - SCOPUS:0026713144

VL - 86

SP - 124

EP - 128

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 2

ER -

Neuropsychological assessment in MS: Clinical, neurophysiological and neuroradiological relationships

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Cite this