Neuropsychological assessment in MS: Clinical, neurophysiological and neuroradiological relationships

M. Maurelli, E. Marchioni, R. Cerretano, D. Bosone, R. Bergamaschi, A. Citterio, A. Martelli, L. Sibilla, F. Savoldi

Research output: Contribution to journalArticlepeer-review


We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent magnetic resonance imaging examination. MS performed worse than controls on all WAIS-P subtests and had learning, short- and long-term verbal memory impairment. Cognitive deficits were not related to abnormal emotional states, but were found to be associated with attentional process and information-processing speed impairment. Cognitive impairment did not correlate with severity of physical disability. The most severe memory deficits were found in patients with extensive periventricular damage.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalActa Neurologica Scandinavica
Issue number2
Publication statusPublished - 1992


  • attention
  • cognitive functioning
  • information processing speed
  • MRI
  • multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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