Abstract
The introduction of highly active antiretroviral therapy does not seem to have altered the incidence of progressive multifocal leukoencephalopathy (PML) in HIV infection. Moreover, the occurrence of a HIV-related leukoencephalopathy, called not determined leukoencephalopaties (NDLE), has been reported. As neuropsychological impairment remains highly prevalent in HIV infection, the aim of this study is to describe the neuropsychological profile of PML and NDLE patients, analyzing the time-related changes. Clinical and neuropsychological data from 32 patients (17 PML, 15 NDLE) were compared with two control groups: (1) asymptomatic HIV+ patients without magnetic resonance imaging evidence of leukoencephalopathy; (2) age-/gender-/education-matched healthy subjects. Patients with rapidly worsening PML were significantly impaired on all neuropsychological tests, while PML with more benign course and NDLE groups showed a dysexecutive pattern of impairment. Asymptomatic HIV+ subjects showed mild and isolated cognitive deficits, without functional impact. Cognitive impairment should therefore be considered a key feature from HIV infection diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 833-839 |
| Number of pages | 7 |
| Journal | Neurological Sciences |
| Volume | 32 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2011 |
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Keywords
- Highly active antiretroviral therapy
- HIV infection
- Leukoencephalopathy
- Neuropsychological evaluation
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
Cite this
Neuropsychological evaluation and follow up in jcv- and non-jcv-related leukoencephalopathies in HIV infection. / Zucchella, C.; Sinforiani, E.; Tavazzi, E.; Del Bue, S.; Novati, S.; Maserati, R.; Ceroni, M.; Bastianello, S.; Minoli, L.; Ferrante, P.; Marchioni, E.
In: Neurological Sciences, Vol. 32, No. 5, 10.2011, p. 833-839.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuropsychological evaluation and follow up in jcv- and non-jcv-related leukoencephalopathies in HIV infection
AU - Zucchella, C.
AU - Sinforiani, E.
AU - Tavazzi, E.
AU - Del Bue, S.
AU - Novati, S.
AU - Maserati, R.
AU - Ceroni, M.
AU - Bastianello, S.
AU - Minoli, L.
AU - Ferrante, P.
AU - Marchioni, E.
PY - 2011/10
Y1 - 2011/10
N2 - The introduction of highly active antiretroviral therapy does not seem to have altered the incidence of progressive multifocal leukoencephalopathy (PML) in HIV infection. Moreover, the occurrence of a HIV-related leukoencephalopathy, called not determined leukoencephalopaties (NDLE), has been reported. As neuropsychological impairment remains highly prevalent in HIV infection, the aim of this study is to describe the neuropsychological profile of PML and NDLE patients, analyzing the time-related changes. Clinical and neuropsychological data from 32 patients (17 PML, 15 NDLE) were compared with two control groups: (1) asymptomatic HIV+ patients without magnetic resonance imaging evidence of leukoencephalopathy; (2) age-/gender-/education-matched healthy subjects. Patients with rapidly worsening PML were significantly impaired on all neuropsychological tests, while PML with more benign course and NDLE groups showed a dysexecutive pattern of impairment. Asymptomatic HIV+ subjects showed mild and isolated cognitive deficits, without functional impact. Cognitive impairment should therefore be considered a key feature from HIV infection diagnosis.
AB - The introduction of highly active antiretroviral therapy does not seem to have altered the incidence of progressive multifocal leukoencephalopathy (PML) in HIV infection. Moreover, the occurrence of a HIV-related leukoencephalopathy, called not determined leukoencephalopaties (NDLE), has been reported. As neuropsychological impairment remains highly prevalent in HIV infection, the aim of this study is to describe the neuropsychological profile of PML and NDLE patients, analyzing the time-related changes. Clinical and neuropsychological data from 32 patients (17 PML, 15 NDLE) were compared with two control groups: (1) asymptomatic HIV+ patients without magnetic resonance imaging evidence of leukoencephalopathy; (2) age-/gender-/education-matched healthy subjects. Patients with rapidly worsening PML were significantly impaired on all neuropsychological tests, while PML with more benign course and NDLE groups showed a dysexecutive pattern of impairment. Asymptomatic HIV+ subjects showed mild and isolated cognitive deficits, without functional impact. Cognitive impairment should therefore be considered a key feature from HIV infection diagnosis.
KW - Highly active antiretroviral therapy
KW - HIV infection
KW - Leukoencephalopathy
KW - Neuropsychological evaluation
UR - http://www.scopus.com/inward/record.url?scp=80054707770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054707770&partnerID=8YFLogxK
U2 - 10.1007/s10072-011-0626-0
DO - 10.1007/s10072-011-0626-0
M3 - Article
C2 - 21630038
AN - SCOPUS:80054707770
VL - 32
SP - 833
EP - 839
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 5
ER -