Neuropsychological features in childhood and juvenile multiple sclerosis: Five-year follow-up

Maria P. Amato, Benedetta Goretti, Angelo Ghezzi, Bahia Hakiki, Claudia Niccolai, Silvia Lori, Lucia Moiola, Monica Falautano, Rosa G. Viterbo, Francesco Patti, Sabina Cilia, Carlo Pozzilli, Valentina Bianchi, Marco Roscio, Vittorio Martinelli, Giancarlo Comi, Emilio Portaccio, Maria Trojano

Research output: Contribution to journalArticlepeer-review


Objective: The aim of the study was to perform a third cognitive assessment in our pediatric-onset multiple sclerosis (MS) patient cohort and determine predictors of the individual cognitive outcome. Methods: After 4.7 6 0.7 years from baseline evaluation, 48 of 63 patients in the original cohort were reassessed on an extensive neuropsychological battery and compared with 46 healthy controls. Two alternate versions of the tests were used at different assessment points. Cognitive impairment was defined as the failure of $3 tests; individual change in the cognitive impairment index was measured. Results: At year 5, 38% of the subjects with MS fulfilled our criterion for impairment. Between years 2 and 5, regarding individual cognitive impairment index change, 66.7% of the patients improved. However, comparing baseline and 5-year testing (when the same versions of the tests were used), cognitive impairment index deterioration was observed in 56% of the patients, improvement in 25%, and stability in 18.8%. A deteriorating performance was related to male sex, younger age and age at MS onset, and lower education. None of these variables, however, was retained in the multivariate analysis. Conclusions: Cognitive outcome in pediatric-onset MS can be heterogeneous. Progression of cognitive problems in a few subjects and potential for compensation and improvement in others call for systematic cognitive screening in this population and development of effective treatment strategies.

Original languageEnglish
Pages (from-to)1432-1438
Number of pages7
Issue number16
Publication statusPublished - Oct 1 2014

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)


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