Neuropsychological findings in patients with Unverricht-Lundborg disease

Edoardo Ferlazzo, Antonella Gagliano, Tiziana Calarese, Adriana Magaudda, Pasquale Striano, Lara Cortese, Clemente Cedro, Virgilie Laguitton, Placido Bramanti, Marilena Carbonaro, Addolorata Albachiara, Nina Fragassi, Domenico Italiano, Edoardo Sessa, Antonietta Coppola, Pierre Genton

Research output: Contribution to journalArticle

Abstract

The aims of this study were to clarify if patients with Unverricht-Lundborg disease (ULD) have adequate cognitive functioning and to delineate their neuropsychological profile. We evaluated 20 patients with ULD and 20 healthy, matched controls. Mean age of the patients was 35 years, and mean duration of disease, 22 years. Patients underwent a neuropsychological battery exploring intelligence, executive functions, visuospatial and verbal memory, depression, and anxiety. Eleven of 20 subjects with ULD had mild to moderate cognitive impairment. Compared with controls, patients with ULD had lower scores on all short-term memory and executive function tasks. Linear regression analysis disclosed significant associations between impaired performance on some memory tests and duration of disease and between severity of myoclonus and performance on most executive function tests. In conclusion, most patients with ULD seem to be impaired with respect to cognitive abilities. Longitudinal prospective studies are needed to confirm and further expand our findings.

Original languageEnglish
Pages (from-to)545-549
Number of pages5
JournalEpilepsy and Behavior
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Neuropsychology
  • Progressive myoclonus epilepsy
  • Unverricht-Lundborg disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

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    Ferlazzo, E., Gagliano, A., Calarese, T., Magaudda, A., Striano, P., Cortese, L., Cedro, C., Laguitton, V., Bramanti, P., Carbonaro, M., Albachiara, A., Fragassi, N., Italiano, D., Sessa, E., Coppola, A., & Genton, P. (2009). Neuropsychological findings in patients with Unverricht-Lundborg disease. Epilepsy and Behavior, 14(3), 545-549. https://doi.org/10.1016/j.yebeh.2009.01.001