Neuropsychological impairment in multiple sclerosis patients: The role of (juxta)cortical lesion on FLAIR

R. H C Lazeron, D. W. Langdon, M. Filippi, J. H T M Van Waesberghe, V. L. Stevenson, J. B S Boringa, D. Origgi, A. J. Thompson, M. Falautano, Ch H. Polman, F. Barkhof

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Abstract

In this study we evaluated the correlation between neuropsychological impairment (measured with the Brief Repeatable Battery Neuropsychological Tests) and (juxta)cortical lesions detected with FLAIR and the relative sensitivity of the FLAIR sequence compared to spin-echo MRI sequences in detecting (juxta)cortical MS lesions. A total of 39 patients with definite MS were evaluated by MRI with a conventional and fast spin echo sequence and fast FLAIR sequence, and neuropsychological tests of the Brief Repeatable Battery Neuropsychological tests were performed. The Z-score of all subtests were used to calculate a Cognitive Impairment Index. The results show that a high number of (juxta)cortical lesions is detected with thin slice FLAIR (30% of all lesions seen). This percentage was not superior to spin-echo, reflecting the thin slice thickness (3 mm) we used. The lesions detected with FLAIR were to a certain degree different ones than the lesions detected with the other techniques. While the number of non-cortical lesions correlated with the expanded disability status scale (r=0.32, P=0.045), the number of (juxta)cortical lesions detected with the FLAIR showed a correlation (r=0.34, P=0.035) with the Cognitive Impairment Index. Our study underlines the high number of (juxta)cortical lesions in MS and the value of thin slice FLAIR sequence to detect such lesions with MRI. It also stresses the importance of (juxta)cortical lesions on determining neuropsychological impairment.

Original languageEnglish
Pages (from-to)280-285
Number of pages6
JournalMultiple Sclerosis Journal
Volume6
Issue number4
Publication statusPublished - 2000

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Neuropsychological Tests
Multiple Sclerosis
Cognitive Dysfunction

Keywords

  • FLAIR
  • Magnetic resonance
  • Multiple sclerosis
  • Neuropsychology

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lazeron, R. H. C., Langdon, D. W., Filippi, M., Van Waesberghe, J. H. T. M., Stevenson, V. L., Boringa, J. B. S., ... Barkhof, F. (2000). Neuropsychological impairment in multiple sclerosis patients: The role of (juxta)cortical lesion on FLAIR. Multiple Sclerosis Journal, 6(4), 280-285.

Neuropsychological impairment in multiple sclerosis patients : The role of (juxta)cortical lesion on FLAIR. / Lazeron, R. H C; Langdon, D. W.; Filippi, M.; Van Waesberghe, J. H T M; Stevenson, V. L.; Boringa, J. B S; Origgi, D.; Thompson, A. J.; Falautano, M.; Polman, Ch H.; Barkhof, F.

In: Multiple Sclerosis Journal, Vol. 6, No. 4, 2000, p. 280-285.

Research output: Contribution to journalArticle

Lazeron, RHC, Langdon, DW, Filippi, M, Van Waesberghe, JHTM, Stevenson, VL, Boringa, JBS, Origgi, D, Thompson, AJ, Falautano, M, Polman, CH & Barkhof, F 2000, 'Neuropsychological impairment in multiple sclerosis patients: The role of (juxta)cortical lesion on FLAIR', Multiple Sclerosis Journal, vol. 6, no. 4, pp. 280-285.
Lazeron RHC, Langdon DW, Filippi M, Van Waesberghe JHTM, Stevenson VL, Boringa JBS et al. Neuropsychological impairment in multiple sclerosis patients: The role of (juxta)cortical lesion on FLAIR. Multiple Sclerosis Journal. 2000;6(4):280-285.
Lazeron, R. H C ; Langdon, D. W. ; Filippi, M. ; Van Waesberghe, J. H T M ; Stevenson, V. L. ; Boringa, J. B S ; Origgi, D. ; Thompson, A. J. ; Falautano, M. ; Polman, Ch H. ; Barkhof, F. / Neuropsychological impairment in multiple sclerosis patients : The role of (juxta)cortical lesion on FLAIR. In: Multiple Sclerosis Journal. 2000 ; Vol. 6, No. 4. pp. 280-285.
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AU - Van Waesberghe, J. H T M

AU - Stevenson, V. L.

AU - Boringa, J. B S

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