Neuropsychological Outcome of Children Treated for Standard Risk Medulloblastoma in the PNET4 European Randomized Controlled Trial of Hyperfractionated Versus Standard Radiation Therapy and Maintenance Chemotherapy

Hugo Câmara-Costa, Anika Resch, Virginie Kieffer, Clémence Lalande, Geraldina Poggi, Colin Kennedy, Kim Bull, Gabriele Calaminus, Jacques Grill, François Doz, Stefan Rutkowski, Maura Massimino, Rolf Dieter Kortmann, Birgitta Lannering, Georges Dellatolas, Mathilde Chevignard

Research output: Contribution to journalArticle

Abstract

Purpose In the European HIT-SIOP PNET4 randomized controlled trial, children with standard risk medulloblastoma were allocated to hyperfractionated radiation therapy (HFRT arm, including a partially focused boost) or standard radiation therapy (STRT arm), followed, in both arms, by maintenance chemotherapy. Event-free survival was similar in both arms. Previous work showed that the HFRT arm was associated with worse growth and better questionnaire-based executive function, especially in children 8 years of age at diagnosis. In children .10]; 5.20 for WMI [95% CI: -2.07 to 12.47; P>.10]; 10.90 for PSI [95% CI: -1.54 to 23.36; P=.08]; and 5.28 for FSIQ [95% CI: -4.23 to 14.79; P>.10]). Conclusions HFRT was associated with marginally higher VIQ in children

Original languageEnglish
Pages (from-to)978-985
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume92
Issue number5
DOIs
Publication statusPublished - Aug 1 2015

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research
  • Medicine(all)

Fingerprint Dive into the research topics of 'Neuropsychological Outcome of Children Treated for Standard Risk Medulloblastoma in the PNET4 European Randomized Controlled Trial of Hyperfractionated Versus Standard Radiation Therapy and Maintenance Chemotherapy'. Together they form a unique fingerprint.

  • Cite this