Neuropsychological outcomes after pulmonary endarterectomy using moderate hypothermia and periodic circulatory arrest

Benedetta Vanini, Valentina Grazioli, Antonio Sciortino, Maurizio Pin, Vera N. Merli, Anna Celentano, Ilaria Parisi, Catherine Klersy, Lucia Petrucci, Maurizio Salati, Pierluigi Politi, Andrea M. D'Armini

Research output: Contribution to journalArticle

Abstract

Background: In this prospective, single-center, observational study, we investigated the association between repeated short periods of circulatory arrest with moderate hypothermia during pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and different neuropsychological dimensions. Methods: We examined 70 patients with CTEPH, >18 to 80 years of age, who had been treated with PEA. Neuropsychological testing was performed. Results: Learning ability and delayed memory remained well within the normal range for patients’ age. We found a statistically significant post-surgical improvement in motor speed, which was accompanied by a better quality of life and reduced symptoms of depression and anxiety. Conclusion: PEA with repeated short periods of circulatory arrest in CTEPH did not result in any neuropsychological complications and may even lead to post-surgical psychological improvements.

Original languageEnglish
Pages (from-to)860-864
Number of pages5
JournalJournal of Heart and Lung Transplantation
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

Keywords

  • chronic thromboembolic pulmonary hypertension
  • circulatory arrest
  • moderate hypothermia
  • neuropsychological dimensions
  • pulmonary endarterectomy

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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