TY - JOUR
T1 - Neuropsychological tests and [99mTc]-HM PAO SPECT in the diagnosis of Alzheimer's dementia
AU - Villa, Giampiero
AU - Cappa, Antonella
AU - Tavolozza, Mario
AU - Gainotti, Guido
AU - Giordano, Alessandro
AU - Calcagni, Maria Lucia
AU - De Rossi, Giuseppe
PY - 1995/6
Y1 - 1995/6
N2 - Twenty-three patients with Alzheimer's dementia (AD) in relatively early stages and 40 patients with other cognitive disorders of vascular or degenerative aetiology underwent neuropsychological examination and [99mTc]-HM PAO single photon emission computed tomography (SPECT). In contrast to the commonly accepted notion of a posterior temporoparietal reduction of tracer uptake as the typical SPECT pattern of AD, the most consistent feature found in the SPECT images of our AD patients was a hippocampal uptake deficit, associated with a variable degree of temporal, parietal and frontal deficit (extending from the posterior to the anterior regions), according to the severity of the disease. These results support the theory of AD as a "hippocampal dementia", at least in the early stages. Neuropsychological tests were found to be somewhat more specific and more accurate than SPECT in distinguishing AD from non-AD cases.
AB - Twenty-three patients with Alzheimer's dementia (AD) in relatively early stages and 40 patients with other cognitive disorders of vascular or degenerative aetiology underwent neuropsychological examination and [99mTc]-HM PAO single photon emission computed tomography (SPECT). In contrast to the commonly accepted notion of a posterior temporoparietal reduction of tracer uptake as the typical SPECT pattern of AD, the most consistent feature found in the SPECT images of our AD patients was a hippocampal uptake deficit, associated with a variable degree of temporal, parietal and frontal deficit (extending from the posterior to the anterior regions), according to the severity of the disease. These results support the theory of AD as a "hippocampal dementia", at least in the early stages. Neuropsychological tests were found to be somewhat more specific and more accurate than SPECT in distinguishing AD from non-AD cases.
KW - [Tc]-HM PAO
KW - Alzheimer's dementia
KW - Neuropsychological tests
KW - Single photon emission computed tomography
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U2 - 10.1007/BF00868390
DO - 10.1007/BF00868390
M3 - Article
C2 - 7561963
AN - SCOPUS:0028989015
VL - 242
SP - 359
EP - 366
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 6
ER -