NEUROPSYCHOPHARMACOLOGY. PROCEEDINGS OF THE CONGRESS OF THE COLLEGIUM INTERNATIONALE NEUROPSYCHOPHARMACOLOGICUM, PARIS, 7-12 JULY, 1974

R. Samanin, C. Bendotti, D. Ghezzi, C. Mauron

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In the present experiments the authors investigated the analgesic effect of morphine and the physical dependence induced by this drug in rats lesioned in the midbrain raphe (MR) or injected intraventricularly with 6 OHDA. The results indicate that it is possible to modify the analgesic effect of morphine by lesioning monoamine neurons in the brain, whereas the physical dependence, assessed as a withdrawal syndrome precipitated by naloxone, is not affected in the same experimental conditions.

Original languageEnglish
Title of host publicationEXCERPTA MEDICA
Pages240-244
Number of pages5
VolumeICS No.359
Publication statusPublished - 1975

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Paris
Analgesics
Morphine Dependence
Oxidopamine
Naloxone
Morphine
Neurons
Brain
Pharmaceutical Preparations
Midbrain Raphe Nuclei

ASJC Scopus subject areas

  • Medicine(all)

Cite this

NEUROPSYCHOPHARMACOLOGY. PROCEEDINGS OF THE CONGRESS OF THE COLLEGIUM INTERNATIONALE NEUROPSYCHOPHARMACOLOGICUM, PARIS, 7-12 JULY, 1974. / Samanin, R.; Bendotti, C.; Ghezzi, D.; Mauron, C.

EXCERPTA MEDICA. Vol. ICS No.359 1975. p. 240-244.

Research output: Chapter in Book/Report/Conference proceedingChapter

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