In the present experiments the authors investigated the analgesic effect of morphine and the physical dependence induced by this drug in rats lesioned in the midbrain raphe (MR) or injected intraventricularly with 6 OHDA. The results indicate that it is possible to modify the analgesic effect of morphine by lesioning monoamine neurons in the brain, whereas the physical dependence, assessed as a withdrawal syndrome precipitated by naloxone, is not affected in the same experimental conditions.
|Title of host publication||EXCERPTA MEDICA|
|Number of pages||5|
|Publication status||Published - 1975|
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