Neuropsycological gender differences in healthy individuals and in pediatric neurodevelopmental disorders. A role for SNAP-25

Alessandro Ghezzo, Franca R. Guerini, Elisabetta Bolognesi, Michela Matteoli, Salvatorica Manca, Stefano Sotgiu, Maurizio Bejor, Mario Clerici, Matteo Chiappedi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Synaptosomal-associated protein of 25 KD (SNAP-25) is a protein that participates in synaptic vesicle exocytosis through the formation of a SNARE complex; SNAP-25 also plays a pivotal role in modulating calcium homeostasis through negative regulation of voltage-gated calcium channels. SNAP-25 has been involved in different neuropsychiatric disorders, including attention deficit hyperactivity disorder. There are well known physiological gender differences in many neuropsychological skills, and there are even more striking gender differences in patients with attention deficit hyperactivity disorder and autism spectrum disorders. We hypothesize that these differences are the result of a mechanism involving SNAP-25 polymorphisms and its differential expression in specific brain areas.

Original languageEnglish
Pages (from-to)978-980
Number of pages3
JournalMedical Hypotheses
Volume73
Issue number6
DOIs
Publication statusPublished - Dec 2009

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Synaptosomal-Associated Protein 25
Pediatrics
Attention Deficit Disorder with Hyperactivity
SNARE Proteins
Synaptic Vesicles
Exocytosis
Calcium Channels
Homeostasis
Calcium
Neurodevelopmental Disorders
Brain
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neuropsycological gender differences in healthy individuals and in pediatric neurodevelopmental disorders. A role for SNAP-25. / Ghezzo, Alessandro; Guerini, Franca R.; Bolognesi, Elisabetta; Matteoli, Michela; Manca, Salvatorica; Sotgiu, Stefano; Bejor, Maurizio; Clerici, Mario; Chiappedi, Matteo.

In: Medical Hypotheses, Vol. 73, No. 6, 12.2009, p. 978-980.

Research output: Contribution to journalArticle

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