Neuroradiologic findings and follow-up with magnetic resonance imaging of the genetic forms of haemophagocytic lymphohistiocytosis with CNS involvement

Research output: Contribution to journalArticle

Abstract

Haemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome caused by deficient down-regulation of the immune response. Presence of central nervous system (CNS) involvement at diagnosis is a poor prognostic sign, and should be carefully investigated. Herein, we describe the neuroradiological findings, clinical data, and treatment outcome in 12 patients with genetic HLH and CNS complications. Neuroimaging was important in identifying CNS involvement, monitoring treatment responses, and detecting treatment complications.

Original languageEnglish
Pages (from-to)810-814
Number of pages5
JournalPediatric Blood and Cancer
Volume58
Issue number5
DOIs
Publication statusPublished - May 2012

Keywords

  • Familial haemophagocytic lymphohistiocytosis
  • Genetic immune deficiency syndromes
  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Fingerprint Dive into the research topics of 'Neuroradiologic findings and follow-up with magnetic resonance imaging of the genetic forms of haemophagocytic lymphohistiocytosis with CNS involvement'. Together they form a unique fingerprint.

  • Cite this