Neuroregulation of growth hormone during exercise in children

M. Cappa, C. Bizzarri, C. Martinez, O. Porzio, G. Giannone, A. Turchetta, A. Calzolari, W. B. Strong

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Physical exercise is an important physiological stimulus to growth hormone (GH) release in man. Many neurotransmitters are involved in GH regulation. We studied the effect of the cholinergic pathway on GH secretion induced by physical exercise. Particularly, we studied the effect of a cholinergic muscarinic agonist on GH-induced physical exercise, both in children and adults. Moreover, we investigated the refractoriness of GH secretion after a second physical exercise stimulus. Three different protocols were performed: 1) GH response to physical exercise in children and adults; 2) effect of pyridostigmine on exercise-induced GH secretion in children and adults; 3) GH response to two consecutive exercises in children and adults. Our data show that in children GH peak after physical exercise is higher than in adults. Pyridostigmine enhances GH release in children and in adults. Exercise stimulus was able to release GH in the second test only in children, while the refractory phase did not permit a new GH release in adults. The shift to a modality of neural control of GH secretion peculiar of adults is likely due to neuroregulatory mechanisms which may be partly dependent on long-term variation in hormonal milieu.

Original languageEnglish
JournalInternational Journal of Sports Medicine, Supplement
Volume21
Issue number2
Publication statusPublished - 2000

Fingerprint

Growth Hormone
Exercise
Pyridostigmine Bromide
Muscarinic Agonists
Cholinergic Agents
Neurotransmitter Agents

Keywords

  • Cholinergic pathway
  • GH-induced physical exercise

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Public Health, Environmental and Occupational Health

Cite this

Cappa, M., Bizzarri, C., Martinez, C., Porzio, O., Giannone, G., Turchetta, A., ... Strong, W. B. (2000). Neuroregulation of growth hormone during exercise in children. International Journal of Sports Medicine, Supplement, 21(2).

Neuroregulation of growth hormone during exercise in children. / Cappa, M.; Bizzarri, C.; Martinez, C.; Porzio, O.; Giannone, G.; Turchetta, A.; Calzolari, A.; Strong, W. B.

In: International Journal of Sports Medicine, Supplement, Vol. 21, No. 2, 2000.

Research output: Contribution to journalArticle

Cappa, M, Bizzarri, C, Martinez, C, Porzio, O, Giannone, G, Turchetta, A, Calzolari, A & Strong, WB 2000, 'Neuroregulation of growth hormone during exercise in children', International Journal of Sports Medicine, Supplement, vol. 21, no. 2.
Cappa, M. ; Bizzarri, C. ; Martinez, C. ; Porzio, O. ; Giannone, G. ; Turchetta, A. ; Calzolari, A. ; Strong, W. B. / Neuroregulation of growth hormone during exercise in children. In: International Journal of Sports Medicine, Supplement. 2000 ; Vol. 21, No. 2.
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