Neuroscience: Breakdown of cortical effective connectivity during sleep

Marcello Massimini, Fabio Ferrarelli, Reto Huber, Steve K. Esser, Harpreet Singh, Giulio Tononi

Research output: Contribution to journalArticle

Abstract

When we fall asleep, consciousness fades yet the brain remains active. Why is this so? To investigate whether changes in cortical information transmission play a role, we used transcranial magnetic stimulation together with high-density electroencephalography and asked how the activation of one cortical area (the premotor area) is transmitted to the rest of the brain. During quiet wakefulness, an initial response (∼15 milliseconds) at the stimulation site was followed by a sequence of waves that moved to connected cortical areas several centimeters away. During non-rapid eye movement sleep, the initial response was stronger but was rapidly extinguished and did not propagate beyond the stimulation site. Thus, the fading of consciousness during certain stages of sleep may be related to a breakdown in cortical effective connectivity.

Original languageEnglish
Pages (from-to)2228-2232
Number of pages5
JournalScience
Volume309
Issue number5744
DOIs
Publication statusPublished - Sep 30 2005

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Neurosciences
Consciousness
Sleep
Transcranial Magnetic Stimulation
Wakefulness
Sleep Stages
Motor Cortex
Brain
Eye Movements
Electroencephalography

ASJC Scopus subject areas

  • General

Cite this

Massimini, M., Ferrarelli, F., Huber, R., Esser, S. K., Singh, H., & Tononi, G. (2005). Neuroscience: Breakdown of cortical effective connectivity during sleep. Science, 309(5744), 2228-2232. https://doi.org/10.1126/science.1117256

Neuroscience : Breakdown of cortical effective connectivity during sleep. / Massimini, Marcello; Ferrarelli, Fabio; Huber, Reto; Esser, Steve K.; Singh, Harpreet; Tononi, Giulio.

In: Science, Vol. 309, No. 5744, 30.09.2005, p. 2228-2232.

Research output: Contribution to journalArticle

Massimini, M, Ferrarelli, F, Huber, R, Esser, SK, Singh, H & Tononi, G 2005, 'Neuroscience: Breakdown of cortical effective connectivity during sleep', Science, vol. 309, no. 5744, pp. 2228-2232. https://doi.org/10.1126/science.1117256
Massimini M, Ferrarelli F, Huber R, Esser SK, Singh H, Tononi G. Neuroscience: Breakdown of cortical effective connectivity during sleep. Science. 2005 Sep 30;309(5744):2228-2232. https://doi.org/10.1126/science.1117256
Massimini, Marcello ; Ferrarelli, Fabio ; Huber, Reto ; Esser, Steve K. ; Singh, Harpreet ; Tononi, Giulio. / Neuroscience : Breakdown of cortical effective connectivity during sleep. In: Science. 2005 ; Vol. 309, No. 5744. pp. 2228-2232.
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