Abstract
Neurosecretion competence is a fundamental property that enables differentiated neurones and professional neurosecretory cells to store neurotransmitters and hormones in specialized organelles, the synaptic-like vesicles and dense granules, and to release them by regulated exocytosis. In our laboratory, the study of rat phaeochromocytoma (PC12) clones that fail to express the above organelles or any other components involved in neurosecretion, whilst maintaining most of the general markers of the parental population, has served to demonstrate that this trait is controlled independently from the rest of the phenotype. The present review focuses on recent advances in elucidating the molecular mechanisms governing neurosecretion competence. Moreover, the opportunities that such neurosecretion-defective PC12 clones offer for the investigation of new aspects of regulated exocytosis and the localization of its components are summarized.
| Original language | English |
|---|---|
| Pages (from-to) | 43-52 |
| Number of pages | 10 |
| Journal | Journal of Physiology |
| Volume | 520 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 1 1999 |
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ASJC Scopus subject areas
- Physiology
Cite this
Neurosecretory cells without neurosecretion : Evidence of an independently regulated trait of the cell phenotype. / Malosio, M. L.; Benfante, R.; Racchetti, G.; Borgonovo, B.; Rosa, P.; Meldolesi, J.
In: Journal of Physiology, Vol. 520, No. 1, 01.10.1999, p. 43-52.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurosecretory cells without neurosecretion
T2 - Evidence of an independently regulated trait of the cell phenotype
AU - Malosio, M. L.
AU - Benfante, R.
AU - Racchetti, G.
AU - Borgonovo, B.
AU - Rosa, P.
AU - Meldolesi, J.
PY - 1999/10/1
Y1 - 1999/10/1
N2 - Neurosecretion competence is a fundamental property that enables differentiated neurones and professional neurosecretory cells to store neurotransmitters and hormones in specialized organelles, the synaptic-like vesicles and dense granules, and to release them by regulated exocytosis. In our laboratory, the study of rat phaeochromocytoma (PC12) clones that fail to express the above organelles or any other components involved in neurosecretion, whilst maintaining most of the general markers of the parental population, has served to demonstrate that this trait is controlled independently from the rest of the phenotype. The present review focuses on recent advances in elucidating the molecular mechanisms governing neurosecretion competence. Moreover, the opportunities that such neurosecretion-defective PC12 clones offer for the investigation of new aspects of regulated exocytosis and the localization of its components are summarized.
AB - Neurosecretion competence is a fundamental property that enables differentiated neurones and professional neurosecretory cells to store neurotransmitters and hormones in specialized organelles, the synaptic-like vesicles and dense granules, and to release them by regulated exocytosis. In our laboratory, the study of rat phaeochromocytoma (PC12) clones that fail to express the above organelles or any other components involved in neurosecretion, whilst maintaining most of the general markers of the parental population, has served to demonstrate that this trait is controlled independently from the rest of the phenotype. The present review focuses on recent advances in elucidating the molecular mechanisms governing neurosecretion competence. Moreover, the opportunities that such neurosecretion-defective PC12 clones offer for the investigation of new aspects of regulated exocytosis and the localization of its components are summarized.
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U2 - 10.1111/j.1469-7793.1999.t01-1-00043.x
DO - 10.1111/j.1469-7793.1999.t01-1-00043.x
M3 - Article
C2 - 10517799
AN - SCOPUS:0033214345
VL - 520
SP - 43
EP - 52
JO - Journal of Physiology
JF - Journal of Physiology
SN - 0022-3751
IS - 1
ER -