Neurotensin-induced miosis: The role of dopaminergic pathways

Cristina Tassorelli, Domenico Spampinato, Paolo Caruso, Sebastiano Cavaliere, Giuseppe Micieli, Filippo Drago, Giuseppe Nappi

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 μg to 4 groups of albino rabbits which had previously undergone the following treatment: a) desmethylimipramine IM and, after 30 min, 6-hydroxydopamine IV 7 days prior to the neurotensin administration; b) haloperidol IM for 15 days; c) haloperidol AC 10 minutes before the neurotensin administration. Our data confirm previous observations regarding the miotic activity of neurotensin and suggest that the dopaminergic system plays an important role in the miotic effect of neurotensin.

Original languageEnglish
Pages (from-to)1309-1311
Number of pages3
JournalPeptides
Volume11
Issue number6
DOIs
Publication statusPublished - 1990

Keywords

  • Dopaminergic system
  • Miosis
  • Neurotensin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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