The authors explore the activity of several enzymes involved in the synthesis of neuronal mediators (namely glutamic decarboxylase, tyrosine hydroxylase, aromatic aminoacid decarboxylase, and dihydropteridine reductase) in various areas of the brain of animals with experimental epilepsy induced by cortical application of cobalt powder. The results indicate an increase of dihydropteridine reductase activity in the injured cortex at 5 postoperative days and a reduction of all other enzymatic activities at 20 days. Various subcortical areas, examined in the same way, showed no appreciable changes of enzymatic activity. The authors discuss the possible meaning of their results and their specificity in relation to the possible involvement of cerebral aminergic systems in the pathogenesis of cobalt-induced epilepsy.
|Translated title of the contribution||Neurotransmitters and experimental epilepsy. Study of the activity of some enzymes involved in the cobalt-powder-induced epilepsy|
|Number of pages||10|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Clinical Neurology