NEUROTRASMETTITORI ED EPILESSIA SPERIMENTALE. STUDIO DELL'ATTIVITA DI ALCUNI ENZIMI DI SINTESI IN RATTI RESI EPILETTICI MEDIANTE POLVERE DI COBALTO

Translated title of the contribution: Neurotransmitters and experimental epilepsy. Study of the activity of some enzymes involved in the cobalt-powder-induced epilepsy

A. C. Altamura, F. Morosini, P. L. Giordano

Research output: Contribution to journalArticlepeer-review

Abstract

The authors explore the activity of several enzymes involved in the synthesis of neuronal mediators (namely glutamic decarboxylase, tyrosine hydroxylase, aromatic aminoacid decarboxylase, and dihydropteridine reductase) in various areas of the brain of animals with experimental epilepsy induced by cortical application of cobalt powder. The results indicate an increase of dihydropteridine reductase activity in the injured cortex at 5 postoperative days and a reduction of all other enzymatic activities at 20 days. Various subcortical areas, examined in the same way, showed no appreciable changes of enzymatic activity. The authors discuss the possible meaning of their results and their specificity in relation to the possible involvement of cerebral aminergic systems in the pathogenesis of cobalt-induced epilepsy.

Translated title of the contributionNeurotransmitters and experimental epilepsy. Study of the activity of some enzymes involved in the cobalt-powder-induced epilepsy
Original languageItalian
Pages (from-to)525-534
Number of pages10
JournalActa Neurologica
Volume32
Issue number5
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Clinical Neurology

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