Neurotransmitters and Neuropeptides: New Players in the Control of Islet of Langerhans' Cell Mass and Function

Eliana S. Di Cairano, Stefania Moretti, Paola Marciani, Vellea Franca Sacchi, Michela Castagna, Alberto Davalli, Franco Folli, Carla Perego

Research output: Contribution to journalArticle

Abstract

Islets of Langerhans control whole body glucose homeostasis, as they respond, releasing hormones, to changes in nutrient concentrations in the blood stream. The regulation of hormone secretion has been the focus of attention for a long time because it is related to many metabolic disorders, including diabetes mellitus. Endocrine cells of the islet use a sophisticate system of endocrine, paracrine and autocrine signals to synchronize their activities. These signals provide a fast and accurate control not only for hormone release but also for cell differentiation and survival, key aspects in islet physiology and pathology. Among the different categories of paracrine/autocrine signals, this review highlights the role of neurotransmitters and neuropeptides. In a manner similar to neurons, endocrine cells synthesize, accumulate, release neurotransmitters in the islet milieu, and possess receptors able to decode these signals. In this review, we provide a comprehensive description of neurotransmitter/neuropetide signaling pathways present within the islet. Then, we focus on evidence supporting the concept that neurotransmitters/neuropeptides and their receptors are interesting new targets to preserve β-cell function and mass. A greater understanding of how this network of signals works in physiological and pathological conditions would advance our knowledge of islet biology and physiology and uncover potentially new areas of pharmacological intervention.

Original languageEnglish
JournalJournal of Cellular Physiology
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

Langerhans Cells
Neuropeptides
Islets of Langerhans
Neurotransmitter Agents
Endocrine Cells
Physiology
Hormones
Cells
Neuropeptide Receptors
Endocrine System
Pathology
Medical problems
Nutrients
Neurons
Cell Differentiation
Cell Survival
Diabetes Mellitus
Homeostasis
Blood
Pharmacology

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Di Cairano, E. S., Moretti, S., Marciani, P., Sacchi, V. F., Castagna, M., Davalli, A., ... Perego, C. (Accepted/In press). Neurotransmitters and Neuropeptides: New Players in the Control of Islet of Langerhans' Cell Mass and Function. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.25176

Neurotransmitters and Neuropeptides : New Players in the Control of Islet of Langerhans' Cell Mass and Function. / Di Cairano, Eliana S.; Moretti, Stefania; Marciani, Paola; Sacchi, Vellea Franca; Castagna, Michela; Davalli, Alberto; Folli, Franco; Perego, Carla.

In: Journal of Cellular Physiology, 2015.

Research output: Contribution to journalArticle

Di Cairano, Eliana S. ; Moretti, Stefania ; Marciani, Paola ; Sacchi, Vellea Franca ; Castagna, Michela ; Davalli, Alberto ; Folli, Franco ; Perego, Carla. / Neurotransmitters and Neuropeptides : New Players in the Control of Islet of Langerhans' Cell Mass and Function. In: Journal of Cellular Physiology. 2015.
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