Neurotrophic keratitis

S. Bonini, P. Rama, D. Olzi, A. Lambiase

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Neurotrophic keratopathy is a degenerative corneal disease induced by an impairment of trigeminal nerve. Impairment of loss of corneal sensory innervation is responsible for corneal epithelial defects, ulcer, and perforation. In the present report, we reviewed the pathogenesis, diagnosis, and therapeutic aspects of this disease. An accurate history and clinical examination,including the function of cranial nerves, together with the clinical features of the ocular surface are essential for a prompt diagnosis. The evaluation of the corneal sensitivity and tear film function are important diagnostic steps as well. Specific medical and surgical treatments, based on the clinical staging of the disease, are often able to halt its progression. Future developments in the medical treatment including the administration of neuropeptide and growth factors are presented.

Original languageEnglish
Pages (from-to)989-995
Number of pages7
JournalEye (London, England)
Volume17
Issue number8
DOIs
Publication statusPublished - Nov 2003

Fingerprint

Keratitis
Corneal Diseases
Trigeminal Nerve
Cranial Nerves
Neuropeptides
Tears
Ulcer
Intercellular Signaling Peptides and Proteins
History
Therapeutics

Keywords

  • Growth factors
  • Medical treatment
  • Neuropeptides
  • Neurotrophic keratitis
  • Pathogenesis
  • Sugical treatment

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Bonini, S., Rama, P., Olzi, D., & Lambiase, A. (2003). Neurotrophic keratitis. Eye (London, England), 17(8), 989-995. https://doi.org/10.1038/sj.eye.6700616

Neurotrophic keratitis. / Bonini, S.; Rama, P.; Olzi, D.; Lambiase, A.

In: Eye (London, England), Vol. 17, No. 8, 11.2003, p. 989-995.

Research output: Contribution to journalArticle

Bonini, S, Rama, P, Olzi, D & Lambiase, A 2003, 'Neurotrophic keratitis', Eye (London, England), vol. 17, no. 8, pp. 989-995. https://doi.org/10.1038/sj.eye.6700616
Bonini, S. ; Rama, P. ; Olzi, D. ; Lambiase, A. / Neurotrophic keratitis. In: Eye (London, England). 2003 ; Vol. 17, No. 8. pp. 989-995.
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