Neutralization activity and kinetics of two broad-range human monoclonal IgG1 derived from recombinant Fab fragments and directed against Hepatitis C Virus E2 glycoprotein

Roberta Antonia Diotti, Giuseppe Andrea Sautto, Laura Solforosi, Nicasio Mancini, Massimo Clementi, Roberto Burioni

Research output: Contribution to journalArticle

Abstract

Hepatitis C virus (HCV) is the major cause of chronic liver disease worldwide. There is evidence that neutralizing an-ti-HCV antibodies may find potential applications in novel prophylactic and therapeutic strategies. This paper describes the very high neutralization activity and unique biological features of two broadly cross-reactive and cross-neutralizing anti-HCV human monoclonal IgG1 derived from human monoclonal recombinant Fab fragments.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalNew Microbiologica
Volume35
Issue number4
Publication statusPublished - 2012

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Keywords

  • E2 glycoprotein
  • Hepatits C virus (HCV)
  • Neutralizing anti-HCV antibodies

ASJC Scopus subject areas

  • Microbiology (medical)

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