Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: The inhibitory effect of prostacyclin (PGI2)

Giovanni Camussi; Ciro Tetta; Giuseppe Segoloni; M. Chiara Deregibus; Federico Bussolino

doi:10.1007/BF01978735

Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: The inhibitory effect of prostacyclin (PGI₂)

Giovanni Camussi, Ciro Tetta, Giuseppe Segoloni, M. Chiara Deregibus, Federico Bussolino

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytes in vitro which was inhibited by ETYA and PGI₂. PGI₂ also inhibited PAF-acether release by PMN leucocytes and, in vivo, PGI₂ abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytes in vivo.

Original language	English
Pages (from-to)	550-553
Number of pages	4
Journal	Agents and Actions
Volume	11
Issue number	6-7
DOIs	https://doi.org/10.1007/BF01978735
Publication status	Published - 1981

ASJC Scopus subject areas

Pharmacology (medical)
Toxicology

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title = "Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: The inhibitory effect of prostacyclin (PGI2)",

abstract = "Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytes in vitro which was inhibited by ETYA and PGI2. PGI2 also inhibited PAF-acether release by PMN leucocytes and, in vivo, PGI2 abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytes in vivo.",

author = "Giovanni Camussi and Ciro Tetta and Giuseppe Segoloni and Deregibus, {M. Chiara} and Federico Bussolino",

year = "1981",

doi = "10.1007/BF01978735",

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T2 - The inhibitory effect of prostacyclin (PGI2)

AU - Camussi, Giovanni

AU - Tetta, Ciro

AU - Segoloni, Giuseppe

AU - Deregibus, M. Chiara

AU - Bussolino, Federico

PY - 1981

Y1 - 1981

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AB - Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytes in vitro which was inhibited by ETYA and PGI2. PGI2 also inhibited PAF-acether release by PMN leucocytes and, in vivo, PGI2 abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytes in vivo.

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