Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: The inhibitory effect of prostacyclin (PGI2)

Giovanni Camussi, Ciro Tetta, Giuseppe Segoloni, M. Chiara Deregibus, Federico Bussolino

Research output: Contribution to journalArticlepeer-review

Abstract

Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytes in vitro which was inhibited by ETYA and PGI2. PGI2 also inhibited PAF-acether release by PMN leucocytes and, in vivo, PGI2 abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytes in vivo.

Original languageEnglish
Pages (from-to)550-553
Number of pages4
JournalAgents and Actions
Volume11
Issue number6-7
DOIs
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology

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