TY - JOUR
T1 - Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils
T2 - The inhibitory effect of prostacyclin (PGI2)
AU - Camussi, Giovanni
AU - Tetta, Ciro
AU - Segoloni, Giuseppe
AU - Deregibus, M. Chiara
AU - Bussolino, Federico
PY - 1981
Y1 - 1981
N2 - Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytes in vitro which was inhibited by ETYA and PGI2. PGI2 also inhibited PAF-acether release by PMN leucocytes and, in vivo, PGI2 abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytes in vivo.
AB - Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytes in vitro which was inhibited by ETYA and PGI2. PGI2 also inhibited PAF-acether release by PMN leucocytes and, in vivo, PGI2 abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytes in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0019803623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019803623&partnerID=8YFLogxK
U2 - 10.1007/BF01978735
DO - 10.1007/BF01978735
M3 - Article
C2 - 7041569
AN - SCOPUS:0019803623
VL - 11
SP - 550
EP - 553
JO - Inflammation Research
JF - Inflammation Research
SN - 1023-3830
IS - 6-7
ER -