Neutrophil CD64 expression: A reliable diagnostic marker of infection in advanced cancer patients?

Giuditta Comolli, Martina Torchio, Elisa Lenta, Benvenuto Franceschetti, Antonella Chiesa, Sandra A. Calarota, Fausto Baldanti, Luigia Scudeller, Piero Marone, Danova Marco

Research output: Contribution to journalArticle

Abstract

Infection and sepsis are major health problems in cancer patients. There is a need for the identification and validation of biomarkers to improve their early diagnosis and treatment. Emerging evidence showed that neutrophil CD64 is a highly sensitive and specific marker for systemic infection and sepsis in critically ill patients with various diseases but data on patients bearing solid tumors are still lacking. Using a dedicated flow cytometric assay we evaluated neutrophil CD64 expression in patients with advanced cancer without active infections to verify if it could be utilized as a reliable biomarker of early infections also in oncologic patients.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalNew Microbiologica
Volume38
Issue number3
Publication statusPublished - Jul 1 2015

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Keywords

  • Cancer patients
  • Flow cytometry
  • Infections
  • Neutrophil CD64
  • Sepsis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Medicine(all)

Cite this

Comolli, G., Torchio, M., Lenta, E., Franceschetti, B., Chiesa, A., Calarota, S. A., Baldanti, F., Scudeller, L., Marone, P., & Marco, D. (2015). Neutrophil CD64 expression: A reliable diagnostic marker of infection in advanced cancer patients? New Microbiologica, 38(3), 427-430.