Neutrophil chemotaxis defect in IgA deficiency evaluated by migration agarose method

R. D'Amelio, S. LeMoli, P. Rossi, F. Aiuti

Research output: Contribution to journalArticle

Abstract

The chemotactic and random mobility functions of twelve selectively IgA-deficient patients were evaluated by a method using agarose gel. A severe polymorphonuclear cellular chemotactic defect was found in ten out of twelve patients, but only five of them also showed a marked associated impairment of random locomotory function. Futhermore, in one subject, levamisole therapy resulted in a dramatic improvement of both chemotactic and random mobility functions. These results are discussed in the paper with respect to the possible pathogenetic implications.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalScandinavian Journal of Immunology
Volume11
Issue number5
Publication statusPublished - 1980

    Fingerprint

ASJC Scopus subject areas

  • Immunology

Cite this