Neutrophil restraint by green tea: Inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis

Massimo Donà, Isabella Dell'Aica, Fiorella Calabrese, Roberto Benelli, Monica Morini, Adriana Albini, Spiridione Garbisa

Research output: Contribution to journalArticle

Abstract

Neutrophils play an essential role in host defense and inflammation, but the latter may trigger and sustain the pathogenesis of a range of acute and chronic diseases. Green tea has been claimed to exert anti-inflammatory properties through unknown molecular mechanisms. We have previously shown that the most abundant catechin of green tea, (-)epigallocatechin-3-gallate (EGCG), strongly inhibits neutrophil elastase. Here we show that 1) micromolar EGCG represses reactive oxygen species activity and inhibits apoptosis of activated neutrophils, and 2) dramatically inhibits chemokine-induced neutrophil chemotaxis in vitro; 3) both oral EGCG and green tea extract block neutrophil-mediated angiogenesis in vivo in an inflammatory angiogenesis model, and 4) oral administration of green tea extract enhances resolution in a pulmonary inflammation model, significantly reducing consequent fibrosis. These results provide molecular and cellular insights into the claimed beneficial properties of green tea and indicate that EGCG is a potent anti-inflammatory compound with therapeutic potential.

Original languageEnglish
Pages (from-to)4335-4341
Number of pages7
JournalJournal of Immunology
Volume170
Issue number8
Publication statusPublished - Apr 15 2003

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Neutrophil restraint by green tea: Inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis'. Together they form a unique fingerprint.

  • Cite this