Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents

A. Romano; N. L. Parrinello; M. L. Consoli; L. Marchionni; S. Forte; C. Conticello; A. Pompa; A. Corso; G. Milone; F. Di Raimondo; I. Borrello

doi:10.1007/s00277-015-2462-4

Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents

A. Romano, N. L. Parrinello, M. L. Consoli, L. Marchionni, S. Forte, C. Conticello, A. Pompa, A. Corso, G. Milone, F. Di Raimondo, I. Borrello

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Recent reports identify the ratio between absolute neutrophil count (ANC) and absolute lymphocyte count (ALC), called neutrophil to lymphocyte ratio (NLR), as a predictor of progression-free survival (PFS) and overall survival (OS) in various malignancies. We retrospectively examined the NLR in a cohort of 309 newly diagnosed multiple myeloma (MM) patients treated upfront with novel agents. NLR was calculated using data obtained from the complete blood count (CBC) at diagnosis and subsequently correlated with PFS and OS. The median NLR was 1.9 (range 0.4–15.9). Higher NLR was independent of international staging system (ISS) stage, plasma cell infiltration or cytogenetics. The 5-year PFS and OS estimates were, respectively, 18.2 and 36.4 % for patients with NLR ≥ 2 versus 25.5 and 66.6 % in patients with NLR <2. Among younger patients (age

Original language	English
Pages (from-to)	1875-1883
Number of pages	9
Journal	Annals of Hematology
Volume	94
Issue number	11
DOIs	https://doi.org/10.1007/s00277-015-2462-4
Publication status	Published - Nov 22 2015

Keywords

Granulocyte
ISS
Lymphocyte
Multiple myeloma

ASJC Scopus subject areas

Hematology
Medicine(all)

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10.1007/s00277-015-2462-4

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Romano, A., Parrinello, N. L., Consoli, M. L., Marchionni, L., Forte, S., Conticello, C., Pompa, A., Corso, A., Milone, G., Di Raimondo, F., & Borrello, I. (2015). Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents. Annals of Hematology, 94(11), 1875-1883. https://doi.org/10.1007/s00277-015-2462-4

Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents. / Romano, A.; Parrinello, N. L.; Consoli, M. L.; Marchionni, L.; Forte, S.; Conticello, C.; Pompa, A.; Corso, A.; Milone, G.; Di Raimondo, F.; Borrello, I.

In: Annals of Hematology, Vol. 94, No. 11, 22.11.2015, p. 1875-1883.

Research output: Contribution to journal › Article › peer-review

Romano, A, Parrinello, NL, Consoli, ML, Marchionni, L, Forte, S, Conticello, C, Pompa, A, Corso, A, Milone, G, Di Raimondo, F & Borrello, I 2015, 'Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents', Annals of Hematology, vol. 94, no. 11, pp. 1875-1883. https://doi.org/10.1007/s00277-015-2462-4

Romano, A. ; Parrinello, N. L. ; Consoli, M. L. ; Marchionni, L. ; Forte, S. ; Conticello, C. ; Pompa, A. ; Corso, A. ; Milone, G. ; Di Raimondo, F. ; Borrello, I. / Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents. In: Annals of Hematology. 2015 ; Vol. 94, No. 11. pp. 1875-1883.

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abstract = "Recent reports identify the ratio between absolute neutrophil count (ANC) and absolute lymphocyte count (ALC), called neutrophil to lymphocyte ratio (NLR), as a predictor of progression-free survival (PFS) and overall survival (OS) in various malignancies. We retrospectively examined the NLR in a cohort of 309 newly diagnosed multiple myeloma (MM) patients treated upfront with novel agents. NLR was calculated using data obtained from the complete blood count (CBC) at diagnosis and subsequently correlated with PFS and OS. The median NLR was 1.9 (range 0.4–15.9). Higher NLR was independent of international staging system (ISS) stage, plasma cell infiltration or cytogenetics. The 5-year PFS and OS estimates were, respectively, 18.2 and 36.4 % for patients with NLR ≥ 2 versus 25.5 and 66.6 % in patients with NLR <2. Among younger patients (age ",

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AU - Marchionni, L.

AU - Forte, S.

AU - Conticello, C.

AU - Pompa, A.

AU - Corso, A.

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AU - Borrello, I.

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