Neutrophilic dermatoses and inflammatory bowel diseases

A. V. Marzano, C. Menicanti, C. Crosti, V. Trevisan

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are inflammatory skin diseases caused by the accumulation of neutrophils in the skin and, rarely, in internal organs, which led to coining the term of neutrophilic dermatoses (ND) to define these conditions. Recently, ND have been included among the autoinflammatory diseases, which are forms due to mutations of genes regulating the innate immune responses. Both PG and SS are frequently associated with inflammatory bowel diseases (IBD), a group of chronic intestinal disorders which comprises ulcerative colitis and Crohn's disease and whose pathogenesis involves both the innate and adaptive immunity in genetically prone individuals. Patients with IBD develop PG in 1-3% of cases, while SS is rarer. PG presents with deep erythematous-to-violaceous painful ulcers with undermined borders, but bullous, pustular, and vegetative variants can also occur. SS, also known as acute febrile neutrophilic dermatosis, is characterized by the abrupt onset of fever, peripheral neutrophilia, tender erythematous skin lesions and a diffuse neutrophilic dermal infiltrate. In this review that will be focused on PG and SS, we will describe also the aseptic abscesses syndrome, a new entity within the spectrum of ND which frequently occurs in association with IBD and is characterized by deep abscesses mainly involving the spleen and skin and by polymorphic cutaneous manifestations including PG- and SS-like lesions.

Original languageEnglish
Pages (from-to)185-196
Number of pages12
JournalGiornale Italiano di Dermatologia e Venereologia
Volume148
Issue number2
Publication statusPublished - 2013

Fingerprint

Sweet Syndrome
Pyoderma Gangrenosum
Inflammatory Bowel Diseases
Skin Diseases
Skin
Innate Immunity
Abscess
Skin Manifestations
Adaptive Immunity
Ulcerative Colitis
Crohn Disease
Ulcer
Neutrophils
Fever
Spleen
Mutation

Keywords

  • Inflammatory bowel diseases
  • Pyoderma gangrenosum
  • Skin diseases
  • Sweet syndrome

ASJC Scopus subject areas

  • Dermatology

Cite this

Neutrophilic dermatoses and inflammatory bowel diseases. / Marzano, A. V.; Menicanti, C.; Crosti, C.; Trevisan, V.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 148, No. 2, 2013, p. 185-196.

Research output: Contribution to journalArticle

Marzano, AV, Menicanti, C, Crosti, C & Trevisan, V 2013, 'Neutrophilic dermatoses and inflammatory bowel diseases', Giornale Italiano di Dermatologia e Venereologia, vol. 148, no. 2, pp. 185-196.
Marzano, A. V. ; Menicanti, C. ; Crosti, C. ; Trevisan, V. / Neutrophilic dermatoses and inflammatory bowel diseases. In: Giornale Italiano di Dermatologia e Venereologia. 2013 ; Vol. 148, No. 2. pp. 185-196.
@article{bebb59eec2a44d9f956b3072d6707cd0,
title = "Neutrophilic dermatoses and inflammatory bowel diseases",
abstract = "Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are inflammatory skin diseases caused by the accumulation of neutrophils in the skin and, rarely, in internal organs, which led to coining the term of neutrophilic dermatoses (ND) to define these conditions. Recently, ND have been included among the autoinflammatory diseases, which are forms due to mutations of genes regulating the innate immune responses. Both PG and SS are frequently associated with inflammatory bowel diseases (IBD), a group of chronic intestinal disorders which comprises ulcerative colitis and Crohn's disease and whose pathogenesis involves both the innate and adaptive immunity in genetically prone individuals. Patients with IBD develop PG in 1-3{\%} of cases, while SS is rarer. PG presents with deep erythematous-to-violaceous painful ulcers with undermined borders, but bullous, pustular, and vegetative variants can also occur. SS, also known as acute febrile neutrophilic dermatosis, is characterized by the abrupt onset of fever, peripheral neutrophilia, tender erythematous skin lesions and a diffuse neutrophilic dermal infiltrate. In this review that will be focused on PG and SS, we will describe also the aseptic abscesses syndrome, a new entity within the spectrum of ND which frequently occurs in association with IBD and is characterized by deep abscesses mainly involving the spleen and skin and by polymorphic cutaneous manifestations including PG- and SS-like lesions.",
keywords = "Inflammatory bowel diseases, Pyoderma gangrenosum, Skin diseases, Sweet syndrome",
author = "Marzano, {A. V.} and C. Menicanti and C. Crosti and V. Trevisan",
year = "2013",
language = "English",
volume = "148",
pages = "185--196",
journal = "Minerva dermatologica",
issn = "0392-0488",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "2",

}

TY - JOUR

T1 - Neutrophilic dermatoses and inflammatory bowel diseases

AU - Marzano, A. V.

AU - Menicanti, C.

AU - Crosti, C.

AU - Trevisan, V.

PY - 2013

Y1 - 2013

N2 - Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are inflammatory skin diseases caused by the accumulation of neutrophils in the skin and, rarely, in internal organs, which led to coining the term of neutrophilic dermatoses (ND) to define these conditions. Recently, ND have been included among the autoinflammatory diseases, which are forms due to mutations of genes regulating the innate immune responses. Both PG and SS are frequently associated with inflammatory bowel diseases (IBD), a group of chronic intestinal disorders which comprises ulcerative colitis and Crohn's disease and whose pathogenesis involves both the innate and adaptive immunity in genetically prone individuals. Patients with IBD develop PG in 1-3% of cases, while SS is rarer. PG presents with deep erythematous-to-violaceous painful ulcers with undermined borders, but bullous, pustular, and vegetative variants can also occur. SS, also known as acute febrile neutrophilic dermatosis, is characterized by the abrupt onset of fever, peripheral neutrophilia, tender erythematous skin lesions and a diffuse neutrophilic dermal infiltrate. In this review that will be focused on PG and SS, we will describe also the aseptic abscesses syndrome, a new entity within the spectrum of ND which frequently occurs in association with IBD and is characterized by deep abscesses mainly involving the spleen and skin and by polymorphic cutaneous manifestations including PG- and SS-like lesions.

AB - Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are inflammatory skin diseases caused by the accumulation of neutrophils in the skin and, rarely, in internal organs, which led to coining the term of neutrophilic dermatoses (ND) to define these conditions. Recently, ND have been included among the autoinflammatory diseases, which are forms due to mutations of genes regulating the innate immune responses. Both PG and SS are frequently associated with inflammatory bowel diseases (IBD), a group of chronic intestinal disorders which comprises ulcerative colitis and Crohn's disease and whose pathogenesis involves both the innate and adaptive immunity in genetically prone individuals. Patients with IBD develop PG in 1-3% of cases, while SS is rarer. PG presents with deep erythematous-to-violaceous painful ulcers with undermined borders, but bullous, pustular, and vegetative variants can also occur. SS, also known as acute febrile neutrophilic dermatosis, is characterized by the abrupt onset of fever, peripheral neutrophilia, tender erythematous skin lesions and a diffuse neutrophilic dermal infiltrate. In this review that will be focused on PG and SS, we will describe also the aseptic abscesses syndrome, a new entity within the spectrum of ND which frequently occurs in association with IBD and is characterized by deep abscesses mainly involving the spleen and skin and by polymorphic cutaneous manifestations including PG- and SS-like lesions.

KW - Inflammatory bowel diseases

KW - Pyoderma gangrenosum

KW - Skin diseases

KW - Sweet syndrome

UR - http://www.scopus.com/inward/record.url?scp=84879005175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879005175&partnerID=8YFLogxK

M3 - Article

VL - 148

SP - 185

EP - 196

JO - Minerva dermatologica

JF - Minerva dermatologica

SN - 0392-0488

IS - 2

ER -