Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities

A Narrative Review

Iman Salem, Mark Kimak, Rosalynn Conic, Nicola L. Bragazzi, Abdulla Watad, Mohammad Adawi, Charlie Bridgewood, Alessia Pacifico, Pierachille Santus, Maurizio Rizzi, Stephen Petrou, Delia Colombo, Marco Fiore, Paolo D.M. Pigatto, Giovanni Damiani

Research output: Contribution to journalReview article

Abstract

Neutrophilic dermatoses (ND) are a polymorphous group of noncontagious dermatological disorders that share the common histological feature of a sterile cutaneous infiltration of mature neutrophils. Clinical manifestations can vary from nodules, pustules, and bulla to erosions and ulcerations. The etiopathogenesis of neutrophilic dermatoses has continuously evolved. Accumulating genetic, clinical, and histological evidence point to NDs being classified in the spectrum of autoinflammatory conditions. However, unlike the monogenic autoinflammatory syndromes where a clear multiple change in the inflammasome structure/function is demonstrated, NDs display several proinflammatory abnormalities, mainly driven by IL-1, IL-17, and tumor necrosis factor-alpha (TNF-a). Additionally, because of the frequent association with extracutaneous manifestations where neutrophils seem to play a crucial role, it was plausible also to consider NDs as a cutaneous presentation of a systemic neutrophilic condition. Neutrophilic dermatoses are more frequently recognized in association with respiratory disorders than by chance alone. The combination of the two, particularly in the context of their overlapping immune responses mediated primarily by neutrophils, raises the likelihood of a common neutrophilic systemic disease or an aberrant innate immunity disorder. Associated respiratory conditions can serve as a trigger or may develop or be exacerbated secondary to the uncontrolled skin disorder. Physicians should be aware of the possible pulmonary comorbidities and apply this knowledge in the three steps of patients' management, work-up, diagnosis, and treatment. In this review, we attempt to unravel the pathophysiological mechanisms of this association and also present some evidence for the role of targeted therapy in the treatment of both conditions.

Original languageEnglish
Article number7315274
JournalBioMed Research International
Volume2019
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Inflammasomes
Interleukin-17
Interleukin-1
Infiltration
Skin Diseases
Comorbidity
Erosion
Skin
Asthma
Tumor Necrosis Factor-alpha
Neutrophils
Neutrophil Infiltration
Blister
Innate Immunity
Therapeutics
Physicians
Lung

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities : A Narrative Review. / Salem, Iman; Kimak, Mark; Conic, Rosalynn; Bragazzi, Nicola L.; Watad, Abdulla; Adawi, Mohammad; Bridgewood, Charlie; Pacifico, Alessia; Santus, Pierachille; Rizzi, Maurizio; Petrou, Stephen; Colombo, Delia; Fiore, Marco; Pigatto, Paolo D.M.; Damiani, Giovanni.

In: BioMed Research International, Vol. 2019, 7315274, 01.01.2019.

Research output: Contribution to journalReview article

Salem, I, Kimak, M, Conic, R, Bragazzi, NL, Watad, A, Adawi, M, Bridgewood, C, Pacifico, A, Santus, P, Rizzi, M, Petrou, S, Colombo, D, Fiore, M, Pigatto, PDM & Damiani, G 2019, 'Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities: A Narrative Review', BioMed Research International, vol. 2019, 7315274. https://doi.org/10.1155/2019/7315274
Salem, Iman ; Kimak, Mark ; Conic, Rosalynn ; Bragazzi, Nicola L. ; Watad, Abdulla ; Adawi, Mohammad ; Bridgewood, Charlie ; Pacifico, Alessia ; Santus, Pierachille ; Rizzi, Maurizio ; Petrou, Stephen ; Colombo, Delia ; Fiore, Marco ; Pigatto, Paolo D.M. ; Damiani, Giovanni. / Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities : A Narrative Review. In: BioMed Research International. 2019 ; Vol. 2019.
@article{40f4ce3dcd934f5ab341817c0d715716,
title = "Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities: A Narrative Review",
abstract = "Neutrophilic dermatoses (ND) are a polymorphous group of noncontagious dermatological disorders that share the common histological feature of a sterile cutaneous infiltration of mature neutrophils. Clinical manifestations can vary from nodules, pustules, and bulla to erosions and ulcerations. The etiopathogenesis of neutrophilic dermatoses has continuously evolved. Accumulating genetic, clinical, and histological evidence point to NDs being classified in the spectrum of autoinflammatory conditions. However, unlike the monogenic autoinflammatory syndromes where a clear multiple change in the inflammasome structure/function is demonstrated, NDs display several proinflammatory abnormalities, mainly driven by IL-1, IL-17, and tumor necrosis factor-alpha (TNF-a). Additionally, because of the frequent association with extracutaneous manifestations where neutrophils seem to play a crucial role, it was plausible also to consider NDs as a cutaneous presentation of a systemic neutrophilic condition. Neutrophilic dermatoses are more frequently recognized in association with respiratory disorders than by chance alone. The combination of the two, particularly in the context of their overlapping immune responses mediated primarily by neutrophils, raises the likelihood of a common neutrophilic systemic disease or an aberrant innate immunity disorder. Associated respiratory conditions can serve as a trigger or may develop or be exacerbated secondary to the uncontrolled skin disorder. Physicians should be aware of the possible pulmonary comorbidities and apply this knowledge in the three steps of patients' management, work-up, diagnosis, and treatment. In this review, we attempt to unravel the pathophysiological mechanisms of this association and also present some evidence for the role of targeted therapy in the treatment of both conditions.",
author = "Iman Salem and Mark Kimak and Rosalynn Conic and Bragazzi, {Nicola L.} and Abdulla Watad and Mohammad Adawi and Charlie Bridgewood and Alessia Pacifico and Pierachille Santus and Maurizio Rizzi and Stephen Petrou and Delia Colombo and Marco Fiore and Pigatto, {Paolo D.M.} and Giovanni Damiani",
year = "2019",
month = "1",
day = "1",
doi = "10.1155/2019/7315274",
language = "English",
volume = "2019",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities

T2 - A Narrative Review

AU - Salem, Iman

AU - Kimak, Mark

AU - Conic, Rosalynn

AU - Bragazzi, Nicola L.

AU - Watad, Abdulla

AU - Adawi, Mohammad

AU - Bridgewood, Charlie

AU - Pacifico, Alessia

AU - Santus, Pierachille

AU - Rizzi, Maurizio

AU - Petrou, Stephen

AU - Colombo, Delia

AU - Fiore, Marco

AU - Pigatto, Paolo D.M.

AU - Damiani, Giovanni

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Neutrophilic dermatoses (ND) are a polymorphous group of noncontagious dermatological disorders that share the common histological feature of a sterile cutaneous infiltration of mature neutrophils. Clinical manifestations can vary from nodules, pustules, and bulla to erosions and ulcerations. The etiopathogenesis of neutrophilic dermatoses has continuously evolved. Accumulating genetic, clinical, and histological evidence point to NDs being classified in the spectrum of autoinflammatory conditions. However, unlike the monogenic autoinflammatory syndromes where a clear multiple change in the inflammasome structure/function is demonstrated, NDs display several proinflammatory abnormalities, mainly driven by IL-1, IL-17, and tumor necrosis factor-alpha (TNF-a). Additionally, because of the frequent association with extracutaneous manifestations where neutrophils seem to play a crucial role, it was plausible also to consider NDs as a cutaneous presentation of a systemic neutrophilic condition. Neutrophilic dermatoses are more frequently recognized in association with respiratory disorders than by chance alone. The combination of the two, particularly in the context of their overlapping immune responses mediated primarily by neutrophils, raises the likelihood of a common neutrophilic systemic disease or an aberrant innate immunity disorder. Associated respiratory conditions can serve as a trigger or may develop or be exacerbated secondary to the uncontrolled skin disorder. Physicians should be aware of the possible pulmonary comorbidities and apply this knowledge in the three steps of patients' management, work-up, diagnosis, and treatment. In this review, we attempt to unravel the pathophysiological mechanisms of this association and also present some evidence for the role of targeted therapy in the treatment of both conditions.

AB - Neutrophilic dermatoses (ND) are a polymorphous group of noncontagious dermatological disorders that share the common histological feature of a sterile cutaneous infiltration of mature neutrophils. Clinical manifestations can vary from nodules, pustules, and bulla to erosions and ulcerations. The etiopathogenesis of neutrophilic dermatoses has continuously evolved. Accumulating genetic, clinical, and histological evidence point to NDs being classified in the spectrum of autoinflammatory conditions. However, unlike the monogenic autoinflammatory syndromes where a clear multiple change in the inflammasome structure/function is demonstrated, NDs display several proinflammatory abnormalities, mainly driven by IL-1, IL-17, and tumor necrosis factor-alpha (TNF-a). Additionally, because of the frequent association with extracutaneous manifestations where neutrophils seem to play a crucial role, it was plausible also to consider NDs as a cutaneous presentation of a systemic neutrophilic condition. Neutrophilic dermatoses are more frequently recognized in association with respiratory disorders than by chance alone. The combination of the two, particularly in the context of their overlapping immune responses mediated primarily by neutrophils, raises the likelihood of a common neutrophilic systemic disease or an aberrant innate immunity disorder. Associated respiratory conditions can serve as a trigger or may develop or be exacerbated secondary to the uncontrolled skin disorder. Physicians should be aware of the possible pulmonary comorbidities and apply this knowledge in the three steps of patients' management, work-up, diagnosis, and treatment. In this review, we attempt to unravel the pathophysiological mechanisms of this association and also present some evidence for the role of targeted therapy in the treatment of both conditions.

UR - http://www.scopus.com/inward/record.url?scp=85068256072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068256072&partnerID=8YFLogxK

U2 - 10.1155/2019/7315274

DO - 10.1155/2019/7315274

M3 - Review article

VL - 2019

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 7315274

ER -