Neutrophilic progression in a case of polycytemia vera mimicking chronic neutrophilic leukemia: Clinical and molecular characterization

Roberto Castelli, Massimo Cugno, Umberto Gianelli, Alessandro Pancrazzi, Alessandro Maria Vannucchi

Research output: Contribution to journalArticle

Abstract

Background: In a small subset of polycytemia vera (PV), neutrophilia not secondary to reactive conditions or treatment can develop and persist. Clinical significance and morphogenetic alterations associated with this uncommon phenomenon are not well defined. Case report: An 81-year-old Caucasian woman, affected by polycytemia vera lasting 17 years, presented in March 2012 with hyperleukocytosis, absolute neutrophilia, and thrombocytosis despite hydroxyurea treatment. All other laboratory parameters were normal, except for an increased neutrophil alkaline phosphatase and lactate dehydrogenase. Reactive neutrophilia due to infection or neoplasia have been ruled out by a total body computerized tomography scan, and by low levels of C reactive protein. Re-evaluation of bone marrow showed hypercellular smears with expansion of granulopoiesis while immature granulocytes were

Original languageEnglish
Pages (from-to)341-343
Number of pages3
JournalPathology Research and Practice
Volume211
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • Chronic neutrophilic leukemia like-evolution
  • Mutational analysis of the gene encoding colony-stimulating factor 3 receptor
  • Myeloproliferative neoplasms
  • Polycythemia vera

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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