TY - JOUR
T1 - Neutrophils engraftment delay during tigecycline treatment in 2 bone marrow-transplanted patients
AU - Maximova, Natalia
AU - Zanon, Davide
AU - Verzegnassi, Federico
AU - Granzotto, Marilena
PY - 2013/1
Y1 - 2013/1
N2 - BACKGROUND: Tigecycline is the first available drug of glycylcycline family. Because of recent introduction, some of its adverse effects could be still unexplored. OBSERVATION: We report the cases of 2 boys who underwent an allogenic bone marrow transplantation for acute myeloid leukemia and were treated with tigecycline. Erythrocyte and platelet engraftment followed a normal course, but the neutrophil count remained low despite the increase in leukocyte count. After tigecycline interruption, the neutrophil count rapidly raised in both cases. CONCLUSIONS: Neutropenia was suspected to be secondary to tigecycline exposure. In vitro experiments were performed, which suggested tigecycline influence on myeloid cells survival.
AB - BACKGROUND: Tigecycline is the first available drug of glycylcycline family. Because of recent introduction, some of its adverse effects could be still unexplored. OBSERVATION: We report the cases of 2 boys who underwent an allogenic bone marrow transplantation for acute myeloid leukemia and were treated with tigecycline. Erythrocyte and platelet engraftment followed a normal course, but the neutrophil count remained low despite the increase in leukocyte count. After tigecycline interruption, the neutrophil count rapidly raised in both cases. CONCLUSIONS: Neutropenia was suspected to be secondary to tigecycline exposure. In vitro experiments were performed, which suggested tigecycline influence on myeloid cells survival.
KW - bone marrow transplantation
KW - engraftment delay
KW - myelotoxicity
KW - tigecycline
UR - http://www.scopus.com/inward/record.url?scp=84871819819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871819819&partnerID=8YFLogxK
U2 - 10.1097/MPH.0b013e318279eec2
DO - 10.1097/MPH.0b013e318279eec2
M3 - Article
C2 - 23171996
AN - SCOPUS:84871819819
VL - 35
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 1
ER -