TY - JOUR
T1 - Neutrophils in innate and adaptive immunity
AU - Jaillon, Sébastien
AU - Galdiero, Maria Rosaria
AU - Del Prete, Davide
AU - Cassatella, Marco Antonio
AU - Garlanda, Cecilia
AU - Mantovani, Alberto
PY - 2013/7
Y1 - 2013/7
N2 - Neutrophils have long been viewed as short-lived cells crucial for the elimination of extracellular pathogens, possessing a limited role in the orchestration of the immune response. This dogma has been challenged by recent lines of evidence demonstrating the expression of an increasing number of cytokines and effector molecules by neutrophils. Moreover, in analogy with their "big brother" macrophages, neutrophils integrate the environmental signals and can be polarized towards an antitumoural or protumoural phenotype. Neutrophils are a major source of humoral fluid phase pattern recognition molecules and thus contribute to the humoral arm of innate immunity. Neutrophils cross talk and shape the maturation and effector functions of other leukocytes in a direct or indirect manner, through cell-cell contact or cytokine production, respectively. Therefore, neutrophils are integrated in the activation and regulation of the innate and adaptive immune system and play an important role in the resolution or exacerbation of diverse pathologies, including infections, chronic inflammation, autoimmunity and cancer.
AB - Neutrophils have long been viewed as short-lived cells crucial for the elimination of extracellular pathogens, possessing a limited role in the orchestration of the immune response. This dogma has been challenged by recent lines of evidence demonstrating the expression of an increasing number of cytokines and effector molecules by neutrophils. Moreover, in analogy with their "big brother" macrophages, neutrophils integrate the environmental signals and can be polarized towards an antitumoural or protumoural phenotype. Neutrophils are a major source of humoral fluid phase pattern recognition molecules and thus contribute to the humoral arm of innate immunity. Neutrophils cross talk and shape the maturation and effector functions of other leukocytes in a direct or indirect manner, through cell-cell contact or cytokine production, respectively. Therefore, neutrophils are integrated in the activation and regulation of the innate and adaptive immune system and play an important role in the resolution or exacerbation of diverse pathologies, including infections, chronic inflammation, autoimmunity and cancer.
KW - Adaptive immunity
KW - Cancer
KW - Inflammation
KW - Innate immunity
KW - Neutrophils
KW - Pattern recognition molecule
UR - http://www.scopus.com/inward/record.url?scp=84879686148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879686148&partnerID=8YFLogxK
U2 - 10.1007/s00281-013-0374-8
DO - 10.1007/s00281-013-0374-8
M3 - Article
C2 - 23553214
AN - SCOPUS:84879686148
VL - 35
SP - 377
EP - 394
JO - Seminars in Immunopathology
JF - Seminars in Immunopathology
SN - 1863-2297
IS - 4
ER -