Neutrophils in the activation and regulation of innate and adaptive immunity

Alberto Mantovani, Marco A. Cassatella, Claudio Costantini, Sébastien Jaillon

Research output: Contribution to journalArticlepeer-review


Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, more recent evidence has extended the functions of these cells. The newly discovered repertoire of effector molecules in the neutrophil armamentarium includes a broad array of cytokines, extracellular traps and effector molecules of the humoral arm of the innate immune system. In addition, neutrophils are involved in the activation, regulation and effector functions of innate and adaptive immune cells. Accordingly, neutrophils have a crucial role in the pathogenesis of a broad range of diseases, including infections caused by intracellular pathogens, autoimmunity, chronic inflammation and cancer.

Original languageEnglish
Pages (from-to)519-531
Number of pages13
JournalNature Reviews Immunology
Issue number8
Publication statusPublished - Aug 2011

ASJC Scopus subject areas

  • Immunology


Dive into the research topics of 'Neutrophils in the activation and regulation of innate and adaptive immunity'. Together they form a unique fingerprint.

Cite this