Nevirapine-based regimens in routine clinical settings: Results from a large italian cohort of HIV-1 infected adults

Raffaella Rosso, Roberto Rossotti, Antonio Di Biagio, Laura Nicolini, Fulvio Adorni, Anna Orani, Claudio Viscoli

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the safety and efficacy of different nevirapine-based regimens in patients starting this drug in a large cohort of Caucasian subjects during the 1999-2007 periods. Methods. A retrospective database review of all patients receiving nevirapine was performed; clinical, biochemical (hepatic and metabolic profiles), immuno-virological parameters were evaluated in the overall population and in different subgroups (according to gender, therapy-experience and HBV/HCV co-infection). We determined risk factors related to dyslipidemia development and to nevirapine interruption within 1 year. Results. We evaluated 277 patients; 58 (20.9%) were naïve, 180 (65%) females and 137 (49.5%) HBV/HCV co-infected. After 48 weeks, 73.6% patients continued antiretroviral regimens. Among these, nevirapine showed little hepatic and metabolic impact, as well as good immuno-virological outcome despite sex, drug experience and co-infection. Factors related to development of dyslipidemia were higher in total cholesterol, female gender with high CD4 count and male gender with low CD4 count (p

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalCurrent Drug Safety
Volume6
Issue number3
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Co-infection
  • Dyslipidemia
  • HBV
  • HCV
  • HIV-1
  • Nevirapine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology
  • Pharmacology

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