Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity

Giuseppina Blanca, Fausto Baldanti, Stefania Paolucci, Alexander Y. Skoblov, Lyubov Victorova, Ulrich Hübscher, Giuseppe Gerna, Silvio Spadari, Giovanni Maga

Research output: Contribution to journalArticlepeer-review

Abstract

Recombinant HIV-1 reverse transcriptase (RT) carrying non-nucleoside inhibitors (NNRTIs) resistance mutation at codon 181 showed reduced incorporation and high efficiency of phosphorolytic removal of stavudine, a nucleoside RT inhibitor. These results reveal a new mechanism for cross-resistance between different classes of HIV-1 RT inhibitors.

Original languageEnglish
Pages (from-to)15469-15472
Number of pages4
JournalJournal of Biological Chemistry
Volume278
Issue number18
DOIs
Publication statusPublished - May 2 2003

ASJC Scopus subject areas

  • Biochemistry

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