New and repurposed drugs for pediatric multidrug-resistant tuberculosis practice-based recommendations

Elizabeth P. Harausz, Anthony J. Garcia-Prats, James A. Seddon, H. Simon Schaaf, Anneke C. Hesseling, Jay Achar, Jonathan Bernheimer, Andrea T. Cruz, Lia D'Ambrosio, Anne Detjen, Stephen M. Graham, Jennifer Hughes, Sylvie Jonckheere, Ben J. Marais, Giovanni Battista Migliori, Lindsay McKenna, Alena Skrahina, Marina Tadolini, Peyton Wilson, Jennifer Furin

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

It is estimated that 33,000 children develop multidrug-resistant tuberculosis (MDR-TB) each year. In spite of these numbers, children and adolescents have limited access to the new and repurposed MDR-TB drugs. There is also little clinical guidance for the use of these drugs and for the shorter MDR-TB regimen in the pediatric population. This is despite the fact that these drugs and regimens are associated with improved interim outcomes and acceptable safety profiles in adults. This review fills a gap in the pediatric MDR-TB literature by providing practice-based recommendations for the use of the new (delamanid and bedaquiline) and repurposed (linezolid and clofazimine) MDR-TB drugs and the new shorter MDR-TB regimen in children and adolescents.

Original languageEnglish
Pages (from-to)1300-1310
Number of pages11
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume195
Issue number10
DOIs
Publication statusPublished - May 15 2017

Fingerprint

Drug Repositioning
Multidrug-Resistant Tuberculosis
Pediatrics
Linezolid
bedaquiline
Pharmaceutical Preparations
Clofazimine
Safety

Keywords

  • Adolescent
  • Child
  • Multidrug-resistant tuberculosis
  • Mycobacterium tuberculosis
  • Pediatric

ASJC Scopus subject areas

  • Medicine(all)
  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Harausz, E. P., Garcia-Prats, A. J., Seddon, J. A., Schaaf, H. S., Hesseling, A. C., Achar, J., ... Furin, J. (2017). New and repurposed drugs for pediatric multidrug-resistant tuberculosis practice-based recommendations. American Journal of Respiratory and Critical Care Medicine, 195(10), 1300-1310. https://doi.org/10.1164/rccm.201606-1227CI

New and repurposed drugs for pediatric multidrug-resistant tuberculosis practice-based recommendations. / Harausz, Elizabeth P.; Garcia-Prats, Anthony J.; Seddon, James A.; Schaaf, H. Simon; Hesseling, Anneke C.; Achar, Jay; Bernheimer, Jonathan; Cruz, Andrea T.; D'Ambrosio, Lia; Detjen, Anne; Graham, Stephen M.; Hughes, Jennifer; Jonckheere, Sylvie; Marais, Ben J.; Migliori, Giovanni Battista; McKenna, Lindsay; Skrahina, Alena; Tadolini, Marina; Wilson, Peyton; Furin, Jennifer.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 195, No. 10, 15.05.2017, p. 1300-1310.

Research output: Contribution to journalReview article

Harausz, EP, Garcia-Prats, AJ, Seddon, JA, Schaaf, HS, Hesseling, AC, Achar, J, Bernheimer, J, Cruz, AT, D'Ambrosio, L, Detjen, A, Graham, SM, Hughes, J, Jonckheere, S, Marais, BJ, Migliori, GB, McKenna, L, Skrahina, A, Tadolini, M, Wilson, P & Furin, J 2017, 'New and repurposed drugs for pediatric multidrug-resistant tuberculosis practice-based recommendations', American Journal of Respiratory and Critical Care Medicine, vol. 195, no. 10, pp. 1300-1310. https://doi.org/10.1164/rccm.201606-1227CI
Harausz, Elizabeth P. ; Garcia-Prats, Anthony J. ; Seddon, James A. ; Schaaf, H. Simon ; Hesseling, Anneke C. ; Achar, Jay ; Bernheimer, Jonathan ; Cruz, Andrea T. ; D'Ambrosio, Lia ; Detjen, Anne ; Graham, Stephen M. ; Hughes, Jennifer ; Jonckheere, Sylvie ; Marais, Ben J. ; Migliori, Giovanni Battista ; McKenna, Lindsay ; Skrahina, Alena ; Tadolini, Marina ; Wilson, Peyton ; Furin, Jennifer. / New and repurposed drugs for pediatric multidrug-resistant tuberculosis practice-based recommendations. In: American Journal of Respiratory and Critical Care Medicine. 2017 ; Vol. 195, No. 10. pp. 1300-1310.
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