New approaches for imaging and therapy of solid cancer

M. Sollini, R. Boni, A. C. Traino, E. Lazzeri, E. Pasqualetti, L. Modeo, G. Mariani, M. Petrini, P. A. Erba

Research output: Contribution to journalArticle

Abstract

Radionuclide therapy is a systemic treatment that aims to deliver cytotoxic radiation to cancer cells. Due to their properties, antibodies have been considered as suitable agent for the delivery of therapeutic radioisotopes, radioimmunotherapy (RIT). This article gives an overview of new approaches for imaging and therapy of solid cancer with particular attention to strategies to enhance treatment success. Examples of increased antibody uptake by targeting stromal constituent of tumor microenvironment such as fibronectin (FN) an important tumor-associated angiogenesis targeting agent, with specifically designed antibody format will be provided. Strategies oriented to identify patients most likely to benefit from RIT including identification of radiosensitivity profiles, in vivo target identification by teragnostic approach and better prediction of dosimetric estimates would be presents. Combination regimens such as with chemo-radiotherapy and immunotherapy would be also discussed as an approach to enhance RIT success.

Original languageEnglish
Pages (from-to)168-183
Number of pages16
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Volume59
Issue number2
Publication statusPublished - Jun 1 2015

Keywords

  • Combined modality therapy
  • Epithelial-mesenchymal transition
  • Radioimmunotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Fingerprint Dive into the research topics of 'New approaches for imaging and therapy of solid cancer'. Together they form a unique fingerprint.

  • Cite this

    Sollini, M., Boni, R., Traino, A. C., Lazzeri, E., Pasqualetti, E., Modeo, L., Mariani, G., Petrini, M., & Erba, P. A. (2015). New approaches for imaging and therapy of solid cancer. Quarterly Journal of Nuclear Medicine and Molecular Imaging, 59(2), 168-183.