New approaches in hepatitis B vaccination for celiac disease

Martina Filippelli, Elena Lionetti, Alfredo Pulvirenti, Alessia Gennaro, Angela Lanzafame, Gianluigi L. Marseglia, Carmelo Salpietro, Mario La Rosa, Salvatore Leonardi

Research output: Contribution to journalArticlepeer-review


Celiac disease (CD) is a gluten-induced immune-mediated disorder that has been associated with a defective response to the hepatitis B virus (HBV) vaccination. This unresponsiveness could lead to a world health problem, because non-responder patients could represent a reservoir of HBV-susceptible people that will persist as healthy carriers, leading to the diffusion of the disease. This article presents a literature review of both intramuscular (IM) and intradermal (ID) routes for boosters in celiac patients. We used PubMed database and generated the odds ratio (OR) of the response on the basis of electronic searches of clinical trials. Although our results confirm the positive response of celiac patients to IM vaccination, the ID route seems to be better than the conventional one, since it could provide a saving in cost and a greater immunogenicity.

Original languageEnglish
Pages (from-to)945-952
Number of pages8
Issue number8
Publication statusPublished - Aug 1 2014


  • celiac disease
  • hepatitis B
  • intradermal route
  • intramuscular route
  • non- responders
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology
  • Medicine(all)


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