New approaches in hepatitis B vaccination for celiac disease

Martina Filippelli, Elena Lionetti, Alfredo Pulvirenti, Alessia Gennaro, Angela Lanzafame, Gianluigi L. Marseglia, Carmelo Salpietro, Mario La Rosa, Salvatore Leonardi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Celiac disease (CD) is a gluten-induced immune-mediated disorder that has been associated with a defective response to the hepatitis B virus (HBV) vaccination. This unresponsiveness could lead to a world health problem, because non-responder patients could represent a reservoir of HBV-susceptible people that will persist as healthy carriers, leading to the diffusion of the disease. This article presents a literature review of both intramuscular (IM) and intradermal (ID) routes for boosters in celiac patients. We used PubMed database and generated the odds ratio (OR) of the response on the basis of electronic searches of clinical trials. Although our results confirm the positive response of celiac patients to IM vaccination, the ID route seems to be better than the conventional one, since it could provide a saving in cost and a greater immunogenicity.

Original languageEnglish
Pages (from-to)945-952
Number of pages8
JournalImmunotherapy
Volume6
Issue number8
DOIs
Publication statusPublished - Aug 1 2014

Fingerprint

Celiac Disease
Hepatitis B
Vaccination
Hepatitis B virus
Abdomen
Glutens
Immune System Diseases
PubMed
Odds Ratio
Clinical Trials
Databases
Costs and Cost Analysis

Keywords

  • celiac disease
  • hepatitis B
  • intradermal route
  • intramuscular route
  • non- responders
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology
  • Medicine(all)

Cite this

Filippelli, M., Lionetti, E., Pulvirenti, A., Gennaro, A., Lanzafame, A., Marseglia, G. L., ... Leonardi, S. (2014). New approaches in hepatitis B vaccination for celiac disease. Immunotherapy, 6(8), 945-952. https://doi.org/10.2217/imt.14.64

New approaches in hepatitis B vaccination for celiac disease. / Filippelli, Martina; Lionetti, Elena; Pulvirenti, Alfredo; Gennaro, Alessia; Lanzafame, Angela; Marseglia, Gianluigi L.; Salpietro, Carmelo; Rosa, Mario La; Leonardi, Salvatore.

In: Immunotherapy, Vol. 6, No. 8, 01.08.2014, p. 945-952.

Research output: Contribution to journalArticle

Filippelli, M, Lionetti, E, Pulvirenti, A, Gennaro, A, Lanzafame, A, Marseglia, GL, Salpietro, C, Rosa, ML & Leonardi, S 2014, 'New approaches in hepatitis B vaccination for celiac disease', Immunotherapy, vol. 6, no. 8, pp. 945-952. https://doi.org/10.2217/imt.14.64
Filippelli M, Lionetti E, Pulvirenti A, Gennaro A, Lanzafame A, Marseglia GL et al. New approaches in hepatitis B vaccination for celiac disease. Immunotherapy. 2014 Aug 1;6(8):945-952. https://doi.org/10.2217/imt.14.64
Filippelli, Martina ; Lionetti, Elena ; Pulvirenti, Alfredo ; Gennaro, Alessia ; Lanzafame, Angela ; Marseglia, Gianluigi L. ; Salpietro, Carmelo ; Rosa, Mario La ; Leonardi, Salvatore. / New approaches in hepatitis B vaccination for celiac disease. In: Immunotherapy. 2014 ; Vol. 6, No. 8. pp. 945-952.
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