New autoantibodies and their clinical associations in juvenile myositis - A systematic review

Daniela Peixoto, José Costa, Marta Ferretti, Clara Malattia, Alberto Martini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Novel autoantibodies targeting intracellular proteins are recently detected in patients with idiopathic inflammatory myopathies (IIMs). Objective. To evaluate the prevalence of these myositis-specific antibodies (MSAs) in juvenile IIMs (JIIMs) and their association with clinical characteristics and disease course. Methods: A systematic literature search was carried out to identify all studies concerning these novel MSAs (p155/140, p140, CADM-140, SAE and 200/100) in patients with JIIMs. Results: A total of 1003 references were identified, of which 118 were selected for detail -ed analysis and 13 included in the final review. Conclusions: The anti-p155/140, the anti-p140 and the anti-CADM-140 seem to be useful markers for define distinct clinical subsets and for predicting pro gnosis of JIIMs. Further studies are needed to clarify the importance of anti 200/100 and anti-SAE in juvenile myositis.

Original languageEnglish
Pages (from-to)234-241
Number of pages8
JournalActa Reumatologica Portuguesa
Volume38
Issue number4
Publication statusPublished - 2013

Keywords

  • Juvenil idiopathic inflammatory myo-pathies
  • Myositis-specific antibodies
  • Novel auto antibodies

ASJC Scopus subject areas

  • Rheumatology
  • Medicine(all)

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