TY - JOUR
T1 - Nuovi indicatori di esposizione
AU - Apostoli, P.
AU - Bergonzi, R.
AU - Catalani, S.
AU - Neri, G.
AU - Sarnico, M.
AU - Foà, V.
AU - Fustinoni, S.
AU - Colombi, A.
AU - Buratti, M.
AU - Campo, L.
AU - Scibetta, L.
AU - Sannolo, N.
AU - Pieri, M.
AU - Basile, A.
AU - Bartolucci, G. B.
AU - Carrieri, M.
AU - Scapellato, M. L.
AU - Manini, P.
AU - Poli, D.
AU - Corradi, M.
AU - Andreoli, R.
AU - Goldoni, M.
AU - Mutti, A.
AU - Imbriani, M.
AU - Ghittori, S.
AU - Maestri, L.
AU - Negri, S.
AU - Pira, E.
AU - Pavan, I.
AU - Discalzi, G.
AU - Perbellini, L.
PY - 2004/10
Y1 - 2004/10
N2 - In this paper we have defined the new biomarkers of exposure (NBE) as those biomarkers discovered in the last fire years and, among previously validated biomarkers, also those applied in different ranges of doses or those determined in biological matrices which differ from matrices originally considered. We examined the results from the surveys carried out by the main Italian research units involved in biological monitoring, i.e. those from the Universities of Brescia, Milan, Naples, Padua, Parma, Pavia, Turin and Verona. The data were collected using a standardized model and included the following: type of element or organic compound, type of biomarker, analytical technique and method, their relationship with environmental monitoring data, their relationship with effect indicators or effects in general, improvement with respect to old biomarkers, reference values. Twenty two NBEs were identified: 14 elements and chemical compounds as such or as metabolites, 4 examples of mixtures, 3 of new matrices, one of speciation. Among the others, aspects such as interest in requiring NBE, quality assurance, availability, cost-benefit ratio were discussed. We conclude that development of this specific field of research appears to be a crucial point for future improvement in risk assessment and health surveillance procedures.
AB - In this paper we have defined the new biomarkers of exposure (NBE) as those biomarkers discovered in the last fire years and, among previously validated biomarkers, also those applied in different ranges of doses or those determined in biological matrices which differ from matrices originally considered. We examined the results from the surveys carried out by the main Italian research units involved in biological monitoring, i.e. those from the Universities of Brescia, Milan, Naples, Padua, Parma, Pavia, Turin and Verona. The data were collected using a standardized model and included the following: type of element or organic compound, type of biomarker, analytical technique and method, their relationship with environmental monitoring data, their relationship with effect indicators or effects in general, improvement with respect to old biomarkers, reference values. Twenty two NBEs were identified: 14 elements and chemical compounds as such or as metabolites, 4 examples of mixtures, 3 of new matrices, one of speciation. Among the others, aspects such as interest in requiring NBE, quality assurance, availability, cost-benefit ratio were discussed. We conclude that development of this specific field of research appears to be a crucial point for future improvement in risk assessment and health surveillance procedures.
KW - Biological monitoring
KW - Exposure biomarkers
KW - Occupational health
KW - Risk assessment
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M3 - Articolo
C2 - 15584435
AN - SCOPUS:8544250599
VL - 26
SP - 278
EP - 297
JO - Giornale Italiano di Medicina del Lavoro ed Ergonomia
JF - Giornale Italiano di Medicina del Lavoro ed Ergonomia
SN - 1592-7830
IS - 4
ER -