Nuovi indicatori di esposizione

Translated title of the contribution: New biomarkers of exposure

P. Apostoli, R. Bergonzi, S. Catalani, G. Neri, M. Sarnico, V. Foà, S. Fustinoni, A. Colombi, M. Buratti, L. Campo, L. Scibetta, N. Sannolo, M. Pieri, A. Basile, G. B. Bartolucci, M. Carrieri, M. L. Scapellato, P. Manini, D. Poli, M. CorradiR. Andreoli, M. Goldoni, A. Mutti, M. Imbriani, S. Ghittori, L. Maestri, S. Negri, E. Pira, I. Pavan, G. Discalzi, L. Perbellini

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper we have defined the new biomarkers of exposure (NBE) as those biomarkers discovered in the last fire years and, among previously validated biomarkers, also those applied in different ranges of doses or those determined in biological matrices which differ from matrices originally considered. We examined the results from the surveys carried out by the main Italian research units involved in biological monitoring, i.e. those from the Universities of Brescia, Milan, Naples, Padua, Parma, Pavia, Turin and Verona. The data were collected using a standardized model and included the following: type of element or organic compound, type of biomarker, analytical technique and method, their relationship with environmental monitoring data, their relationship with effect indicators or effects in general, improvement with respect to old biomarkers, reference values. Twenty two NBEs were identified: 14 elements and chemical compounds as such or as metabolites, 4 examples of mixtures, 3 of new matrices, one of speciation. Among the others, aspects such as interest in requiring NBE, quality assurance, availability, cost-benefit ratio were discussed. We conclude that development of this specific field of research appears to be a crucial point for future improvement in risk assessment and health surveillance procedures.

Translated title of the contributionNew biomarkers of exposure
Original languageItalian
Pages (from-to)278-297
Number of pages20
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume26
Issue number4
Publication statusPublished - Oct 2004

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation

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