New classification of acute myeloid leukemia and precursor-related neoplasms

changes and unsolved issues.

Brunangelo Falini, Enrico Tiacci, Maria Paola Martelli, Stefano Ascani, Stefano A. Pileri

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The World Health Organization (WHO) classification of lympho-hematopoietic neoplasms is increasingly based on genetic criteria. Here, we focus on changes that, as compared to the 2001 edition, were introduced into the 2008 WHO classification of acute myeloid leukemia (AML) and related precursor neoplasms. The category of AML with recurrent genetic abnormalities was expanded to account for 60% of AML by adding three distinct entities, i.e., AML with t(6,9), inv(3), or t(1;22), and two provisional entities, i.e., AML with mutated NPM1 or CEBPA. These changes have greatly modified the approaches to diagnosis and prognostic stratification of AML patients. To emphasize the need of various parameters for diagnosis, including myelodysplasia (MD)-related cytogenetic abnormalities, history of myelodysplasia or myelodysplasia/myeloproliferative neoplasm, and multilineage dysplasia, the category of "AML with multilineage dysplasia" was re-named AML with MD-related changes. Finally, we describe the unique characteristics of myeloid proliferations associated with Down syndrome and blastic plasmacytoid dendritic cell neoplasm.

Original languageEnglish
Pages (from-to)281-292
Number of pages12
JournalDiscovery medicine
Volume10
Issue number53
Publication statusPublished - Oct 2010

Fingerprint

Acute Myeloid Leukemia
Neoplasms
Hematologic Neoplasms
Down Syndrome
Chromosome Aberrations
Dendritic Cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

New classification of acute myeloid leukemia and precursor-related neoplasms : changes and unsolved issues. / Falini, Brunangelo; Tiacci, Enrico; Martelli, Maria Paola; Ascani, Stefano; Pileri, Stefano A.

In: Discovery medicine, Vol. 10, No. 53, 10.2010, p. 281-292.

Research output: Contribution to journalArticle

Falini, Brunangelo ; Tiacci, Enrico ; Martelli, Maria Paola ; Ascani, Stefano ; Pileri, Stefano A. / New classification of acute myeloid leukemia and precursor-related neoplasms : changes and unsolved issues. In: Discovery medicine. 2010 ; Vol. 10, No. 53. pp. 281-292.
@article{42e486debf9945bcad2625da2d9a6588,
title = "New classification of acute myeloid leukemia and precursor-related neoplasms: changes and unsolved issues.",
abstract = "The World Health Organization (WHO) classification of lympho-hematopoietic neoplasms is increasingly based on genetic criteria. Here, we focus on changes that, as compared to the 2001 edition, were introduced into the 2008 WHO classification of acute myeloid leukemia (AML) and related precursor neoplasms. The category of AML with recurrent genetic abnormalities was expanded to account for 60{\%} of AML by adding three distinct entities, i.e., AML with t(6,9), inv(3), or t(1;22), and two provisional entities, i.e., AML with mutated NPM1 or CEBPA. These changes have greatly modified the approaches to diagnosis and prognostic stratification of AML patients. To emphasize the need of various parameters for diagnosis, including myelodysplasia (MD)-related cytogenetic abnormalities, history of myelodysplasia or myelodysplasia/myeloproliferative neoplasm, and multilineage dysplasia, the category of {"}AML with multilineage dysplasia{"} was re-named AML with MD-related changes. Finally, we describe the unique characteristics of myeloid proliferations associated with Down syndrome and blastic plasmacytoid dendritic cell neoplasm.",
author = "Brunangelo Falini and Enrico Tiacci and Martelli, {Maria Paola} and Stefano Ascani and Pileri, {Stefano A.}",
year = "2010",
month = "10",
language = "English",
volume = "10",
pages = "281--292",
journal = "Discovery medicine",
issn = "1539-6509",
publisher = "Discovery Medicine",
number = "53",

}

TY - JOUR

T1 - New classification of acute myeloid leukemia and precursor-related neoplasms

T2 - changes and unsolved issues.

AU - Falini, Brunangelo

AU - Tiacci, Enrico

AU - Martelli, Maria Paola

AU - Ascani, Stefano

AU - Pileri, Stefano A.

PY - 2010/10

Y1 - 2010/10

N2 - The World Health Organization (WHO) classification of lympho-hematopoietic neoplasms is increasingly based on genetic criteria. Here, we focus on changes that, as compared to the 2001 edition, were introduced into the 2008 WHO classification of acute myeloid leukemia (AML) and related precursor neoplasms. The category of AML with recurrent genetic abnormalities was expanded to account for 60% of AML by adding three distinct entities, i.e., AML with t(6,9), inv(3), or t(1;22), and two provisional entities, i.e., AML with mutated NPM1 or CEBPA. These changes have greatly modified the approaches to diagnosis and prognostic stratification of AML patients. To emphasize the need of various parameters for diagnosis, including myelodysplasia (MD)-related cytogenetic abnormalities, history of myelodysplasia or myelodysplasia/myeloproliferative neoplasm, and multilineage dysplasia, the category of "AML with multilineage dysplasia" was re-named AML with MD-related changes. Finally, we describe the unique characteristics of myeloid proliferations associated with Down syndrome and blastic plasmacytoid dendritic cell neoplasm.

AB - The World Health Organization (WHO) classification of lympho-hematopoietic neoplasms is increasingly based on genetic criteria. Here, we focus on changes that, as compared to the 2001 edition, were introduced into the 2008 WHO classification of acute myeloid leukemia (AML) and related precursor neoplasms. The category of AML with recurrent genetic abnormalities was expanded to account for 60% of AML by adding three distinct entities, i.e., AML with t(6,9), inv(3), or t(1;22), and two provisional entities, i.e., AML with mutated NPM1 or CEBPA. These changes have greatly modified the approaches to diagnosis and prognostic stratification of AML patients. To emphasize the need of various parameters for diagnosis, including myelodysplasia (MD)-related cytogenetic abnormalities, history of myelodysplasia or myelodysplasia/myeloproliferative neoplasm, and multilineage dysplasia, the category of "AML with multilineage dysplasia" was re-named AML with MD-related changes. Finally, we describe the unique characteristics of myeloid proliferations associated with Down syndrome and blastic plasmacytoid dendritic cell neoplasm.

UR - http://www.scopus.com/inward/record.url?scp=79952196999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952196999&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 281

EP - 292

JO - Discovery medicine

JF - Discovery medicine

SN - 1539-6509

IS - 53

ER -