New clinical criteria for the assessment of liver involvement in Hodgkin's disease

Paolo G. Gobbi, Giuseppe Attardo Parrinello, Ubaldo Di Prisco, Massimo Federico, Goretta Bonacorsi, Daniele Dini, Sandra Marabelli, Salvatore C. Rizzo, Edoardo Ascari

Research output: Contribution to journalArticlepeer-review


The hepatic involvement in Hodgkin's disease, histologically verified in 133 patients who underwent laparotomy or laparoscopy, proved to be singly related to the following clinical findings: result of the liver isotopic scan, liver and/or spleen enlargement, serum albumin ≤ 3.5 g/dl, GOT and/or GPT ≥ 20 mU/ml, serum alkaline phosphatase (SAP) ≥ 210 mU/ml, BSP retention at 45 min ≥ 6.5% and ESR ≥ 51 mm at 1 hr. Such clinical findings were jointly evaluated and further selected by means of a logistic discriminant analysis, and the simplest function with the best discriminant ability between involved and non-involved liver was made by liver scan, spleen enlargement, BSP retention and GOT (89.5% of correct diagnoses). Since the Ann Arbor clinical criteria for liver involvement showed correct diagnoses in 69-80% of the cases, more reliable criteria can be proposed. So, liver involvement is highly probably (a) when three or more of the five variables indicated above are abnormal, or (b) when a markedly abnormal liver scan is associated with alteration of at least one of the other four parameters: otherwise liver will be non-involved.

Original languageEnglish
Pages (from-to)1243-1249
Number of pages7
JournalEuropean Journal of Cancer and Clinical Oncology
Issue number12
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Oncology


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