New concepts on intestinal microbiota and the role of the non-absorbable antibiotics with special reference to rifaximin in digestive diseases

Jasmohan S. Bajaj, Giovanni Barbara, Herbert L. DuPont, F. Mearin, Antonio Gasbarrini, Jan Tack

Research output: Contribution to journalReview articlepeer-review

Abstract

Digestive diseases are a broad range of chronic disorders that substantially and negatively impact the patients’ quality of life. Here, we review our current understanding on the pathophysiology of hepatic encephalopathy, irritable bowel syndrome, and diverticular disease, with a special focus on the gut microbiota composition associated with these disorders. Furthermore, we review the current clinical practice for their therapeutic treatments, including probiotics, diet change, non-adsorbable disaccharides, and antibiotics. We highlight that broad-spectrum non-adsorbable antibiotics, such as rifaximin, are quite effective and safe for the treatment of all essayed digestive diseases.

Original languageEnglish
Pages (from-to)741-749
Number of pages9
JournalDigestive and Liver Disease
Volume50
Issue number8
DOIs
Publication statusPublished - Aug 1 2018

Keywords

  • Antibiotics
  • Gut microenvironment
  • Therapeutic treatments

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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