New developments in our understanding of DISH (diffuse idiopathic skeletal hyperostosis)

Piercarlo Sarzi-Puttini, Fabiola Atzeni

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Purpose of review: Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is a common disorder among older adults. The diagnosis is based solely on radiographic abnormalities defined using the Resnick criteria. DISH is characterized by ossification of the anterior longitudinal ligament of the spine and various extraspinal ligaments. DISH often coexists with OA, but patients affected by this disorder differ from patients with primary OA in several aspects: prevalence in the general population, gender distribution, anatomic site of primary involvement, magnitude and distribution in the spine and the peripheral joints. Purpose of this review is to summarize new clinical, pathogenetic and therapeutic insights of this disease. Recent findings: Recent studies confirm that patients with DISH have a greater body mass index, higher serum uric acid levels and are more likely to have diabetes mellitus. In addition, DISH is most probably related to abnormal bone cell growth/activity reflecting the influence of metabolic factors that lead to new bone formation. Serum matrix Gla protein may be a marker of osteometabolic syndromes, such as DISH, that cause hyperostosis. Summary: Many recent developments of DISH are described in this review. Possible pathogenetic mechanism driving bone deposition are discussed. DISH is still recognized radiographically; no specific drug has been yet identified.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalCurrent Opinion in Rheumatology
Volume16
Issue number3
DOIs
Publication statusPublished - May 2004

Fingerprint

Diffuse Idiopathic Skeletal Hyperostosis
Osteogenesis
Spine
Longitudinal Ligaments
Hyperostosis
Bone Development
Uric Acid
Serum
Ligaments
Diabetes Mellitus
Body Mass Index
Joints
Demography

Keywords

  • Diffuse idiopathic skeletal hyperostosis
  • Forestier's disease
  • Matrix Gla protein
  • Ossification of ligamentum flavum
  • Ossification of posterior longitudinal ligament

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

New developments in our understanding of DISH (diffuse idiopathic skeletal hyperostosis). / Sarzi-Puttini, Piercarlo; Atzeni, Fabiola.

In: Current Opinion in Rheumatology, Vol. 16, No. 3, 05.2004, p. 287-292.

Research output: Contribution to journalArticle

Sarzi-Puttini, Piercarlo ; Atzeni, Fabiola. / New developments in our understanding of DISH (diffuse idiopathic skeletal hyperostosis). In: Current Opinion in Rheumatology. 2004 ; Vol. 16, No. 3. pp. 287-292.
@article{750727df99704e01ac79e78a58fd4812,
title = "New developments in our understanding of DISH (diffuse idiopathic skeletal hyperostosis)",
abstract = "Purpose of review: Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is a common disorder among older adults. The diagnosis is based solely on radiographic abnormalities defined using the Resnick criteria. DISH is characterized by ossification of the anterior longitudinal ligament of the spine and various extraspinal ligaments. DISH often coexists with OA, but patients affected by this disorder differ from patients with primary OA in several aspects: prevalence in the general population, gender distribution, anatomic site of primary involvement, magnitude and distribution in the spine and the peripheral joints. Purpose of this review is to summarize new clinical, pathogenetic and therapeutic insights of this disease. Recent findings: Recent studies confirm that patients with DISH have a greater body mass index, higher serum uric acid levels and are more likely to have diabetes mellitus. In addition, DISH is most probably related to abnormal bone cell growth/activity reflecting the influence of metabolic factors that lead to new bone formation. Serum matrix Gla protein may be a marker of osteometabolic syndromes, such as DISH, that cause hyperostosis. Summary: Many recent developments of DISH are described in this review. Possible pathogenetic mechanism driving bone deposition are discussed. DISH is still recognized radiographically; no specific drug has been yet identified.",
keywords = "Diffuse idiopathic skeletal hyperostosis, Forestier's disease, Matrix Gla protein, Ossification of ligamentum flavum, Ossification of posterior longitudinal ligament",
author = "Piercarlo Sarzi-Puttini and Fabiola Atzeni",
year = "2004",
month = "5",
doi = "10.1097/00002281-200405000-00021",
language = "English",
volume = "16",
pages = "287--292",
journal = "Current Opinion in Rheumatology",
issn = "1040-8711",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - New developments in our understanding of DISH (diffuse idiopathic skeletal hyperostosis)

AU - Sarzi-Puttini, Piercarlo

AU - Atzeni, Fabiola

PY - 2004/5

Y1 - 2004/5

N2 - Purpose of review: Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is a common disorder among older adults. The diagnosis is based solely on radiographic abnormalities defined using the Resnick criteria. DISH is characterized by ossification of the anterior longitudinal ligament of the spine and various extraspinal ligaments. DISH often coexists with OA, but patients affected by this disorder differ from patients with primary OA in several aspects: prevalence in the general population, gender distribution, anatomic site of primary involvement, magnitude and distribution in the spine and the peripheral joints. Purpose of this review is to summarize new clinical, pathogenetic and therapeutic insights of this disease. Recent findings: Recent studies confirm that patients with DISH have a greater body mass index, higher serum uric acid levels and are more likely to have diabetes mellitus. In addition, DISH is most probably related to abnormal bone cell growth/activity reflecting the influence of metabolic factors that lead to new bone formation. Serum matrix Gla protein may be a marker of osteometabolic syndromes, such as DISH, that cause hyperostosis. Summary: Many recent developments of DISH are described in this review. Possible pathogenetic mechanism driving bone deposition are discussed. DISH is still recognized radiographically; no specific drug has been yet identified.

AB - Purpose of review: Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is a common disorder among older adults. The diagnosis is based solely on radiographic abnormalities defined using the Resnick criteria. DISH is characterized by ossification of the anterior longitudinal ligament of the spine and various extraspinal ligaments. DISH often coexists with OA, but patients affected by this disorder differ from patients with primary OA in several aspects: prevalence in the general population, gender distribution, anatomic site of primary involvement, magnitude and distribution in the spine and the peripheral joints. Purpose of this review is to summarize new clinical, pathogenetic and therapeutic insights of this disease. Recent findings: Recent studies confirm that patients with DISH have a greater body mass index, higher serum uric acid levels and are more likely to have diabetes mellitus. In addition, DISH is most probably related to abnormal bone cell growth/activity reflecting the influence of metabolic factors that lead to new bone formation. Serum matrix Gla protein may be a marker of osteometabolic syndromes, such as DISH, that cause hyperostosis. Summary: Many recent developments of DISH are described in this review. Possible pathogenetic mechanism driving bone deposition are discussed. DISH is still recognized radiographically; no specific drug has been yet identified.

KW - Diffuse idiopathic skeletal hyperostosis

KW - Forestier's disease

KW - Matrix Gla protein

KW - Ossification of ligamentum flavum

KW - Ossification of posterior longitudinal ligament

UR - http://www.scopus.com/inward/record.url?scp=2142712605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2142712605&partnerID=8YFLogxK

U2 - 10.1097/00002281-200405000-00021

DO - 10.1097/00002281-200405000-00021

M3 - Article

C2 - 15103260

AN - SCOPUS:2142712605

VL - 16

SP - 287

EP - 292

JO - Current Opinion in Rheumatology

JF - Current Opinion in Rheumatology

SN - 1040-8711

IS - 3

ER -