New diagnostic possibilities in systemic neonatal infections

Metabolomics

Angelica Dessì, Giovanni Corsello, Mauro Stronati, Diego Gazzolo, Pierluigi Caboni, Roberta Carboni, Vassilios Fanos

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Systemic neonatal infection is a serious complication in preterm and term infants and is defined as a complex clinical syndrome caused by bacteria, fungi and virus. Sepsis remains among the leading causes of death in both developed and underdeveloped countries above all in the neonatal period. Earlier diagnosis may offer the ability to initiate treatment to prevent adverse outcomes. There have been many studies on various diagnostic haematological markers like acute phase reactants, C-reactive protein, procalcitonin, interleukins and presepsin. However, there is still no single test that satisfies the criteria as being the ideal marker for the early diagnosis of neonatal sepsis. In this regard, metabolomic analysis seems to be a promising method for determining metabolic variations correlated with systemic neonatal infections.

Original languageEnglish
JournalEarly Human Development
Volume90
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2014

Fingerprint

Metabolomics
Early Diagnosis
Acute-Phase Proteins
Interleukins
Calcitonin
Infection
Developed Countries
Premature Infants
C-Reactive Protein
Cause of Death
Sepsis
Fungi
Viruses
Bacteria
Therapeutics
Neonatal Sepsis

Keywords

  • Metabolomics
  • Neonatal infections
  • Newborn
  • Sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology
  • Medicine(all)

Cite this

New diagnostic possibilities in systemic neonatal infections : Metabolomics. / Dessì, Angelica; Corsello, Giovanni; Stronati, Mauro; Gazzolo, Diego; Caboni, Pierluigi; Carboni, Roberta; Fanos, Vassilios.

In: Early Human Development, Vol. 90, No. SUPPL.1, 2014.

Research output: Contribution to journalArticle

Dessì, Angelica ; Corsello, Giovanni ; Stronati, Mauro ; Gazzolo, Diego ; Caboni, Pierluigi ; Carboni, Roberta ; Fanos, Vassilios. / New diagnostic possibilities in systemic neonatal infections : Metabolomics. In: Early Human Development. 2014 ; Vol. 90, No. SUPPL.1.
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